Asset Manager
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BAKER BROS. ADVISORS LP
Market Value
$10.2B
+15.1%
Holdings
91
+3
New Purchases
12
Added To
21
Closed
11
Reduced
8
Top 10 Concentration
82.7%
Turnover
25.3%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| INSM | 7.63% | 4.64% | +2.99% | $776M |
| SMMT | 7.05% | 5.33% | +1.72% | $718M |
| ACAD | 9.10% | 8.06% | +1.04% | $925M |
| KYMR | 2.85% | 1.86% | +1.00% | $290M |
| GPCR | 0.51% | 0.07% | +0.44% | $52M |
| GRAL | 0.82% | 0.47% | +0.35% | $84M |
| RARE | 0.99% | 0.65% | +0.35% | $101M |
| BNTX | 0.39% | 0.05% | +0.34% | $39M |
| IDYA | 0.44% | 0.20% | +0.24% | $45M |
| VRDN | 0.24% | 0.00% | +0.24% | $24M |
| ABCL | 0.93% | 0.69% | +0.23% | $94M |
| CELC | 0.72% | 0.49% | +0.23% | $73M |
| RVMD | 3.39% | 3.18% | +0.21% | $345M |
| NTLA | 0.25% | 0.05% | +0.19% | $25M |
| MRUS | 0.30% | 0.11% | +0.19% | $30M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ONC | 20.94% | 27.10% | -6.16% | $2.1B |
| MDGL | 5.88% | 7.40% | -1.52% | $598M |
| EWTX | 0.94% | 1.53% | -0.59% | $96M |
| INCY | 20.58% | 21.06% | -0.48% | $2.1B |
| ARGX | 0.20% | 0.52% | -0.32% | $21M |
| BCYC | 0.74% | 1.05% | -0.30% | $76M |
| CRSP | 0.00% | 0.25% | -0.25% | $0 |
| REPL | 1.01% | 1.22% | -0.21% | $103M |
| CNTA | 0.00% | 0.20% | -0.20% | $0 |
| IMVT | 0.86% | 1.06% | -0.20% | $87M |
| TRDA | 0.32% | 0.50% | -0.18% | $33M |
| TSVT | 0.00% | 0.14% | -0.14% | $0 |
| CADL | 0.02% | 0.16% | -0.14% | $2M |
| CERS | 0.18% | 0.30% | -0.13% | $18M |
| BCAX | 0.00% | 0.12% | -0.12% | $0 |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 12 | $6.8B | 66.8% |
| Mid Cap | 31 | $2.5B | 25.0% |
| Small Cap | 33 | $751M | 7.4% |
| Micro Cap | 15 | $77M | 0.8% |
Portfolio Analytics
Avg Market Cap
$5.5B
Median Market Cap
$1.9B
Avg P/E
36.3
Median P/E
26.8
Avg Dividend Yield
—%
Avg Beta
1.00
# Stocks
91
# ETFs / Funds
0
Top Holdings (91 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | ONC | 20.94% | 8,799,053 | $2.1B | $242.07 | -$265M | — | — | |
| 2 | INCY | 20.58% | 30,743,275 | $2.1B | $68.10 | $232M | +3,322 | +0.0% | |
| 3 | ACAD | 9.10% | 42,896,690 | $925M | $21.57 | $213M | +18,774 | +0.0% | |
| 4 | INSM | 7.63% | 7,712,900 | $776M | $100.64 | $366M | +2,332,274 | +43.4% | |
| 5 | SMMT | 7.05% | 33,722,974 | $718M | $21.28 | $246M | +9,298,109 | +38.1% | |
| 6 | MDGL | 5.88% | 1,976,018 | $598M | $302.64 | -$56M | +1,428 | +0.1% | |
| 7 | RYTM | 3.48% | 5,604,483 | $354M | $63.19 | $57M | — | — | |
| 8 | RVMD | 3.39% | 9,364,972 | $345M | $36.79 | $64M | +1,428,000 | +18.0% | |
| 9 | KYMR | 2.85% | 6,651,429 | $290M | $43.64 | $126M | +655,500 | +10.9% | |
| 10 | ALKS | 1.80% | 6,410,603 | $183M | $28.61 | $35M | +1,927,318 | +43.0% | |
| 11 | REPL | 1.01% | 11,045,336 | $103M | $9.29 | -$5M | — | — | |
| 12 | RARE | 0.99% | 2,772,692 | $101M | $36.36 | $44M | +1,196,578 | +75.9% | |
| 13 | EWTX | 0.94% | 7,305,940 | $96M | $13.11 | -$40M | +1,150,000 | +18.7% | |
| 14 | ABCL | 0.93% | 27,525,640 | $94M | $3.43 | $33M | — | — | |
| 15 | IMVT | 0.86% | 5,457,881 | $87M | $16.00 | -$6M | — | — | |
| 16 | GRAL | 0.82% | 1,630,125 | $84M | $51.42 | $42M | — | — | |
| 17 | BCYC | 0.74% | 10,885,357 | $76M | $6.95 | -$17M | — | — | |
| 18 | IMCR | 0.72% | 2,322,656 | $73M | $31.38 | $4M | — | — | |
| 19 | CELC | 0.72% | 5,450,445 | $73M | $13.35 | $30M | +1,192,710 | +28.0% | |
| 20 | KOD | 0.63% | 17,310,490 | $65M | $3.73 | $16M | — | — | |
| 21 | IMTX | 0.54% | 10,168,901 | $55M | $5.38 | $22M | +2,893,071 | +39.8% | |
| 22 | STOK | 0.52% | 4,633,838 | $53M | $11.35 | $22M | — | — | |
| 23 | DNLI | 0.51% | 3,731,695 | $52M | $13.99 | $1M | — | — | |
| 24 | GPCR | 0.51% | 2,508,767 | $52M | $20.74 | $46M | +2,147,202 | +593.9% | |
| 25 | IDYA | 0.44% | 2,118,728 | $45M | $21.02 | $27M | +1,056,605 | +99.5% | |
| 26 | NRIX | 0.43% | 3,882,125 | $44M | $11.39 | -$2M | — | — | |
| 27 | ROIV | 0.42% | 3,767,773 | $42M | $11.27 | $4M | — | — | |
| 28 | BNTX | 0.39% | 368,923 | $39M | $106.47 | $35M | +323,892 | +719.3% | |
| 29 | TRDA | 0.32% | 4,865,819 | $33M | $6.72 | -$11M | — | — | |
| 30 | MRUS | 0.30% | 574,377 | $30M | $52.60 | $21M | +350,877 | +157.0% | |
| 31 | NTLA | 0.25% | 2,675,674 | $25M | $9.38 | $21M | +2,031,558 | +315.4% | |
| 32 | VRDN | 0.24% | 1,744,406 | $24M | $13.98 | — | +1,744,406 | — | NEW |
| 33 | GLUE | 0.22% | 4,916,095 | $22M | $4.51 | -$639K | — | — | |
| 34 | VRNA | 0.21% | 223,843 | $21M | $94.58 | $7M | — | — | |
| 35 | PCVX | 0.20% | 640,885 | $21M | $32.51 | -$3M | — | — | |
| 36 | ARGX | 0.20% | 37,760 | $21M | $551.22 | -$25M | -40,000 | -51.4% | |
| 37 | VERV | 0.19% | 1,691,530 | $19M | $11.23 | $11M | — | — | |
| 38 | CERS | 0.18% | 12,883,844 | $18M | $1.41 | -$9M | -6,467,243 | -33.4% | |
| 39 | IRON | 0.18% | 337,050 | $18M | $52.96 | $14M | +260,000 | +337.4% | |
| 40 | AKRO | 0.17% | 324,630 | $17M | $53.36 | -$5M | -224,083 | -40.8% | |
| 41 | BPMC | 0.16% | 125,538 | $16M | $128.18 | — | +125,538 | — | NEW |
| 42 | SERA | 0.15% | 5,498,170 | $15M | $2.77 | -$5M | — | — | |
| 43 | ARWR | 0.15% | 939,174 | $15M | $15.80 | — | +939,174 | — | NEW |
| 44 | NGNE | 0.15% | 991,691 | $15M | $14.95 | -$3M | -494,509 | -33.3% | |
| 45 | DNTH | 0.14% | 789,759 | $15M | $18.63 | — | +789,759 | — | NEW |
| 46 | CLDX | 0.13% | 665,370 | $14M | $20.35 | $9M | +417,726 | +168.7% | |
| 47 | XENE | 0.11% | 370,208 | $12M | $31.30 | -$68K | +22,800 | +6.6% | |
| 48 | CDTX | 0.11% | 227,272 | $11M | $48.71 | — | +227,272 | — | NEW |
| 49 | ACLX | 0.11% | 166,825 | $11M | $65.85 | — | +166,825 | — | NEW |
| 50 | NUVL | 0.11% | 143,937 | $11M | $76.30 | — | +143,937 | — | NEW |
| 51 | SYRE | 0.09% | 626,703 | $9M | $14.97 | — | +626,703 | — | NEW |
| 52 | TSHA | 0.09% | 4,004,756 | $9M | $2.31 | $4M | — | — | |
| 53 | PRLD | 0.08% | 10,123,824 | $8M | $0.81 | $419K | — | — | |
| 54 | CRNX | 0.08% | 280,000 | $8M | $28.76 | — | +280,000 | — | NEW |
| 55 | CTMX | 0.08% | 3,484,226 | $8M | $2.27 | — | +3,484,226 | — | NEW |
| 56 | SGMT | 0.07% | 952,996 | $7M | $7.62 | $4M | — | — | |
| 57 | SION | 0.07% | 400,000 | $7M | $17.35 | $3M | — | — | |
| 58 | AGIO | 0.06% | 189,866 | $6M | $33.26 | — | +189,866 | — | NEW |
| 59 | RAPP | 0.06% | 550,090 | $6M | $11.37 | — | +550,090 | — | NEW |
| 60 | DSGN | 0.06% | 1,712,882 | $6M | $3.37 | -$958K | -30,843 | -1.8% | |
| 61 | SANA | 0.05% | 2,030,949 | $6M | $2.73 | $2M | — | — | |
| 62 | XNCR | 0.05% | 670,431 | $5M | $7.86 | -$2M | — | — | |
| 63 | ALMS | 0.05% | 1,562,500 | $5M | $3.00 | -$5M | — | — | |
| 64 | IGMS | 0.05% | 4,096,210 | $5M | $1.12 | -$122K | +953 | +0.0% | |
| 65 | TCRX | 0.04% | 2,784,792 | $4M | $1.45 | $195K | — | — | |
| 66 | RLAY | 0.04% | 1,160,117 | $4M | $3.46 | $974K | — | — | |
| 67 | FATE | 0.03% | 2,485,018 | $3M | $1.12 | $209K | -773,384 | -23.7% | |
| 68 | VIR | 0.03% | 542,539 | $3M | $5.04 | -$781K | — | — | |
| 69 | ELVN | 0.02% | 114,833 | $2M | $20.06 | $44K | — | — | |
| 70 | WVE | 0.02% | 344,063 | $2M | $6.50 | -$544K | — | — | |
| 71 | TECX | 0.02% | 100,000 | $2M | $19.87 | $216K | — | — | |
| 72 | CADL | 0.02% | 355,112 | $2M | $5.06 | -$12M | -2,082,077 | -85.4% | |
| 73 | TARA | 0.02% | 536,832 | $2M | $3.03 | -$660K | — | — | |
| 74 | RCKT | 0.01% | 552,079 | $1M | $2.45 | -$6M | -545,000 | -49.7% | |
| 75 | CTNM | 0.01% | 312,500 | $1M | $3.97 | -$941K | — | — | |
| 76 | HOOK | 0.01% | 812,814 | $1M | $1.26 | $142K | — | — | |
| 77 | NMRA | 0.01% | 1,034,600 | $759K | $0.73 | -$276K | — | — | |
| 78 | TYRA | —% | 10,607 | $102K | $9.57 | $3K | — | — | |
| 79 | ACRV | —% | 22,809 | $27K | $1.19 | -$19K | — | — | |
| 80 | SRZNW | —% | 833,333 | $15K | $0.02 | -$10K | — | — | |
| 81 | BCAX | —% | — | — | — | -$11M | -833,333 | -100.0% | SOLD |
| 82 | TSVT | —% | — | — | — | -$12M | -2,497,526 | -100.0% | SOLD |
| 83 | IPSC | —% | — | — | — | -$115K | -241,684 | -100.0% | SOLD |
| 84 | CRSP | —% | — | — | — | -$22M | -654,099 | -100.0% | SOLD |
| 85 | CMPX | —% | — | — | — | -$1M | -547,498 | -100.0% | SOLD |
| 86 | RGLS | —% | — | — | — | -$5M | -2,694,044 | -100.0% | SOLD |
| 87 | DYN | —% | — | — | — | -$7M | -672,096 | -100.0% | SOLD |
| 88 | PRME | —% | — | — | — | -$2M | -1,028,466 | -100.0% | SOLD |
| 89 | IONS | —% | — | — | — | -$11M | -357,915 | -100.0% | SOLD |
| 90 | CYPH | —% | — | — | — | -$123K | -404,744 | -100.0% | SOLD |
| 91 | CNTA | —% | — | — | — | -$18M | -1,227,178 | -100.0% | SOLD |