Asset Manager
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BAKER BROS. ADVISORS LP
Market Value
$13.6B
+33.9%
Holdings
90
-1
New Purchases
10
Added To
13
Closed
9
Reduced
4
Top 10 Concentration
80.3%
Turnover
21.1%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| CELC | 2.87% | 0.72% | +2.15% | $391M |
| KOD | 2.08% | 0.63% | +1.45% | $283M |
| MDGL | 7.21% | 5.88% | +1.33% | $982M |
| ONC | 22.00% | 20.94% | +1.06% | $3.0B |
| RYTM | 4.15% | 3.48% | +0.67% | $566M |
| ABVX | 0.55% | 0.00% | +0.55% | $74M |
| STOK | 0.80% | 0.52% | +0.28% | $109M |
| ARWR | 0.42% | 0.15% | +0.28% | $58M |
| RAPP | 0.34% | 0.06% | +0.28% | $46M |
| IONS | 0.27% | 0.00% | +0.27% | $37M |
| IMTX | 0.76% | 0.54% | +0.22% | $103M |
| IDYA | 0.65% | 0.44% | +0.22% | $89M |
| RNAM | 0.20% | 0.00% | +0.20% | $27M |
| NTLA | 0.35% | 0.25% | +0.10% | $47M |
| MRUS | 0.40% | 0.30% | +0.10% | $54M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ACAD | 6.72% | 9.10% | -2.38% | $915M |
| SMMT | 5.11% | 7.05% | -1.94% | $697M |
| INCY | 19.14% | 20.58% | -1.44% | $2.6B |
| REPL | 0.34% | 1.01% | -0.67% | $46M |
| INSM | 7.09% | 7.63% | -0.55% | $965M |
| RARE | 0.61% | 0.99% | -0.38% | $83M |
| IMVT | 0.65% | 0.86% | -0.21% | $88M |
| VRNA | 0.00% | 0.21% | -0.21% | $0 |
| GPCR | 0.32% | 0.51% | -0.19% | $44M |
| VERV | 0.00% | 0.19% | -0.19% | $0 |
| NRIX | 0.26% | 0.43% | -0.17% | $36M |
| BPMC | 0.00% | 0.16% | -0.16% | $0 |
| RVMD | 3.24% | 3.39% | -0.15% | $442M |
| BCYC | 0.62% | 0.74% | -0.13% | $84M |
| BNTX | 0.27% | 0.39% | -0.12% | $36M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 13 | $8.9B | 65.6% |
| Mid Cap | 30 | $3.4B | 25.1% |
| Small Cap | 34 | $1.2B | 8.8% |
| Micro Cap | 13 | $80M | 0.6% |
Portfolio Analytics
Avg Market Cap
$5.7B
Median Market Cap
$1.9B
Avg P/E
36.3
Median P/E
26.8
Avg Dividend Yield
—%
Avg Beta
0.98
# Stocks
90
# ETFs / Funds
0
Top Holdings (90 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | ONC | 22.00% | 8,799,053 | $3.0B | $340.70 | $868M | — | — | |
| 2 | INCY | 19.14% | 30,743,663 | $2.6B | $84.81 | $514M | +388 | — | |
| 3 | MDGL | 7.21% | 2,141,701 | $982M | $458.66 | $384M | +165,683 | +8.4% | |
| 4 | INSM | 7.09% | 6,703,484 | $965M | $144.01 | $189M | -1,009,416 | -13.1% | |
| 5 | ACAD | 6.72% | 42,896,690 | $915M | $21.34 | -$10M | — | — | |
| 6 | SMMT | 5.11% | 33,722,974 | $697M | $20.66 | -$21M | — | — | |
| 7 | RYTM | 4.15% | 5,604,483 | $566M | $100.99 | $212M | — | — | |
| 8 | RVMD | 3.24% | 9,455,357 | $442M | $46.70 | $97M | +90,385 | +1.0% | |
| 9 | CELC | 2.87% | 7,915,792 | $391M | $49.40 | $318M | +2,465,347 | +45.2% | |
| 10 | KYMR | 2.76% | 6,651,429 | $376M | $56.60 | $86M | — | — | |
| 11 | KOD | 2.08% | 17,310,490 | $283M | $16.37 | $219M | — | — | |
| 12 | ALKS | 1.78% | 8,091,351 | $243M | $30.00 | $59M | +1,680,748 | +26.2% | |
| 13 | ABCL | 1.02% | 27,525,640 | $138M | $5.03 | $44M | — | — | |
| 14 | EWTX | 0.87% | 7,305,940 | $119M | $16.22 | $23M | — | — | |
| 15 | STOK | 0.80% | 4,633,838 | $109M | $23.50 | $56M | — | — | |
| 16 | IMTX | 0.76% | 12,094,094 | $103M | $8.52 | $48M | +1,925,193 | +18.9% | |
| 17 | GRAL | 0.71% | 1,630,125 | $96M | $59.13 | $13M | — | — | |
| 18 | IDYA | 0.65% | 3,275,444 | $89M | $27.21 | $45M | +1,156,716 | +54.6% | |
| 19 | IMVT | 0.65% | 5,457,881 | $88M | $16.12 | $655K | — | — | |
| 20 | IMCR | 0.62% | 2,322,656 | $84M | $36.33 | $11M | — | — | |
| 21 | BCYC | 0.62% | 10,885,357 | $84M | $7.74 | $9M | — | — | |
| 22 | RARE | 0.61% | 2,772,692 | $83M | $30.08 | -$17M | — | — | |
| 23 | ABVX | 0.55% | 875,796 | $74M | $84.90 | — | +875,796 | — | NEW |
| 24 | ARWR | 0.42% | 1,670,762 | $58M | $34.49 | $43M | +731,588 | +77.9% | |
| 25 | ROIV | 0.42% | 3,767,773 | $57M | $15.13 | $15M | — | — | |
| 26 | DNLI | 0.40% | 3,731,695 | $54M | $14.52 | $2M | — | — | |
| 27 | MRUS | 0.40% | 574,377 | $54M | $94.15 | $24M | — | — | |
| 28 | NTLA | 0.35% | 2,746,674 | $47M | $17.27 | $22M | +71,000 | +2.6% | |
| 29 | REPL | 0.34% | 11,045,336 | $46M | $4.19 | -$56M | — | — | |
| 30 | RAPP | 0.34% | 1,547,090 | $46M | $29.70 | $40M | +997,000 | +181.2% | |
| 31 | GPCR | 0.32% | 1,556,109 | $44M | $28.00 | -$8M | -952,658 | -38.0% | |
| 32 | VRDN | 0.28% | 1,744,406 | $38M | $21.58 | $13M | — | — | |
| 33 | IONS | 0.27% | 566,798 | $37M | $65.42 | — | +566,798 | — | NEW |
| 34 | GLUE | 0.27% | 4,916,095 | $36M | $7.41 | $14M | — | — | |
| 35 | BNTX | 0.27% | 368,923 | $36M | $98.62 | -$3M | — | — | |
| 36 | NRIX | 0.26% | 3,882,125 | $36M | $9.24 | -$8M | — | — | |
| 37 | DNTH | 0.23% | 789,759 | $31M | $39.35 | $16M | — | — | |
| 38 | TRDA | 0.21% | 4,865,819 | $28M | $5.80 | -$4M | — | — | |
| 39 | ARGX | 0.20% | 37,760 | $28M | $737.56 | $7M | — | — | |
| 40 | RNAM | 0.20% | 625,000 | $27M | $43.57 | — | +625,000 | — | NEW |
| 41 | PCVX | 0.17% | 640,885 | $23M | $36.02 | $2M | — | — | |
| 42 | IRON | 0.16% | 337,050 | $22M | $66.08 | $4M | — | — | |
| 43 | CDTX | 0.16% | 227,272 | $22M | $95.76 | $11M | — | — | |
| 44 | CLDX | 0.13% | 665,370 | $17M | $25.87 | $4M | — | — | |
| 45 | NGNE | 0.13% | 991,691 | $17M | $17.33 | $2M | — | — | |
| 46 | SERA | 0.12% | 5,498,170 | $17M | $3.06 | $2M | — | — | |
| 47 | SYRE | 0.12% | 1,000,000 | $17M | $16.76 | $7M | +373,297 | +59.6% | |
| 48 | CERS | 0.12% | 10,008,345 | $16M | $1.59 | -$2M | -2,875,499 | -22.3% | |
| 49 | AKRO | 0.11% | 324,630 | $15M | $47.48 | -$2M | — | — | |
| 50 | XENE | 0.11% | 370,208 | $15M | $40.15 | $3M | — | — | |
| 51 | PRLD | 0.11% | 10,123,824 | $15M | $1.44 | $6M | — | — | |
| 52 | ACLX | 0.10% | 166,825 | $14M | $82.10 | $3M | — | — | |
| 53 | CTMX | 0.10% | 4,250,826 | $14M | $3.19 | $6M | +766,600 | +22.0% | |
| 54 | TSHA | 0.10% | 4,004,756 | $13M | $3.27 | $4M | — | — | |
| 55 | XNCR | 0.09% | 1,102,106 | $13M | $11.73 | $8M | +431,675 | +64.4% | |
| 56 | DSGN | 0.09% | 1,712,882 | $13M | $7.53 | $7M | — | — | |
| 57 | NUVL | 0.09% | 143,937 | $12M | $86.48 | $1M | — | — | |
| 58 | SION | 0.09% | 400,000 | $12M | $29.41 | $5M | — | — | |
| 59 | CRNX | 0.09% | 280,000 | $12M | $41.65 | $4M | — | — | |
| 60 | VKTX | 0.07% | 366,083 | $10M | $26.28 | — | +366,083 | — | NEW |
| 61 | PHVS | 0.07% | 375,000 | $9M | $24.95 | — | +375,000 | — | NEW |
| 62 | AGIO | 0.06% | 189,866 | $8M | $40.14 | $1M | — | — | |
| 63 | SANA | 0.05% | 2,030,949 | $7M | $3.55 | $2M | — | — | |
| 64 | SGMT | 0.05% | 952,996 | $7M | $6.86 | -$724K | — | — | |
| 65 | ALMS | 0.05% | 1,562,500 | $6M | $3.99 | $2M | — | — | |
| 66 | RLAY | 0.04% | 1,160,117 | $6M | $5.22 | $2M | — | — | |
| 67 | HRTX | 0.04% | 4,251,951 | $5M | $1.26 | — | +4,251,951 | — | NEW |
| 68 | TCRX | 0.04% | 2,784,792 | $5M | $1.82 | $1M | — | — | |
| 69 | MBX | 0.04% | 277,777 | $5M | $17.50 | — | +277,777 | — | NEW |
| 70 | VTYX | 0.02% | 1,023,130 | $3M | $3.11 | — | +1,023,130 | — | NEW |
| 71 | LBRX | 0.02% | 200,000 | $3M | $15.79 | — | +200,000 | — | NEW |
| 72 | VIR | 0.02% | 542,539 | $3M | $5.71 | $364K | — | — | |
| 73 | WVE | 0.02% | 344,063 | $3M | $7.32 | $282K | — | — | |
| 74 | ELVN | 0.02% | 114,833 | $2M | $20.47 | $47K | — | — | |
| 75 | TARA | 0.02% | 536,832 | $2M | $4.35 | $709K | — | — | |
| 76 | TECX | 0.01% | 100,000 | $2M | $15.69 | -$418K | — | — | |
| 77 | GBIO | 0.01% | 194,493 | $1M | $6.12 | — | +194,493 | — | NEW |
| 78 | CTNM | 0.01% | 77,670 | $913K | $11.75 | -$328K | -234,830 | -75.2% | |
| 79 | TYRA | —% | 10,607 | $148K | $13.99 | $47K | — | — | |
| 80 | ACRV | —% | 22,809 | $41K | $1.81 | $14K | — | — | |
| 81 | SRZNW | —% | 833,333 | $15K | $0.02 | -$250 | — | — | |
| 82 | BPMC | —% | — | — | — | -$16M | -125,538 | -100.0% | SOLD |
| 83 | HOOK | —% | — | — | — | -$1M | -812,814 | -100.0% | SOLD |
| 84 | VERV | —% | — | — | — | -$19M | -1,691,530 | -100.0% | SOLD |
| 85 | VRNA | —% | — | — | — | -$21M | -223,843 | -100.0% | SOLD |
| 86 | RCKT | —% | — | — | — | -$1M | -552,079 | -100.0% | SOLD |
| 87 | CADL | —% | — | — | — | -$2M | -355,112 | -100.0% | SOLD |
| 88 | FATE | —% | — | — | — | -$3M | -2,485,018 | -100.0% | SOLD |
| 89 | IGMS | —% | — | — | — | -$5M | -4,096,210 | -100.0% | SOLD |
| 90 | NMRA | —% | — | — | — | -$759K | -1,034,600 | -100.0% | SOLD |