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Asset Manager ← All Institutions

DAFNA Capital Management LLC

Q4 2025 · Filed 2026-02-17
Market Value
$403M
+5.4%
Holdings
77
+3
New Purchases
10
Added To
15
Closed
7
Reduced
28
Top 10 Concentration
58.5%
Turnover
22.1%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
RVMD 11.95% 8.02% +3.92% $48M
PRCT 0.94% 0.00% +0.94% $4M
CYBN 0.92% 0.00% +0.92% $4M
MBX 1.29% 0.39% +0.90% $5M
TNDM 1.94% 1.13% +0.81% $8M
DNLI 1.30% 0.64% +0.67% $5M
MPLT 0.63% 0.00% +0.63% $3M
PROF 0.56% 0.00% +0.56% $2M
IDYA 4.35% 3.84% +0.51% $18M
DAWN 2.31% 1.84% +0.47% $9M
IPSC 0.69% 0.22% +0.47% $3M
AXGN 3.87% 3.46% +0.41% $16M
ATRC 5.86% 5.46% +0.41% $24M
ATXS 0.99% 0.61% +0.38% $4M
BCRX 0.81% 0.43% +0.38% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 5.43% -5.43% $0
STXS 7.81% 11.12% -3.32% $31M
IBB 2.85% 3.87% -1.02% $11M
CMPX 0.00% 0.87% -0.87% $0
KRRO 0.00% 0.76% -0.76% $0
SNDX 1.45% 2.01% -0.57% $6M
MLYS 0.35% 0.83% -0.48% $1M
KURA 0.61% 1.07% -0.46% $2M
XBI 10.18% 10.52% -0.34% $41M
KROS 0.00% 0.33% -0.33% $0
BDTX 0.00% 0.30% -0.30% $0
ALEC 0.35% 0.62% -0.27% $1M
ARAY 0.29% 0.53% -0.25% $1M
BCAX 1.09% 1.31% -0.22% $4M
STOK 0.86% 1.04% -0.19% $3M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 6 $69M 17.2%
Mid Cap 18 $166M 41.3%
Small Cap 33 $108M 26.8%
Micro Cap 20 $60M 14.8%

Portfolio Analytics

Avg Market Cap
$3.1B
Median Market Cap
$1.1B
Avg P/E
31.2
Median P/E
28.5
Avg Dividend Yield
—%
Avg Beta
1.03
# Stocks
75
# ETFs / Funds
2

Top Holdings (77 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 RVMD 11.95% 604,514 $48M $79.65 $17M -52,662 -8.0%
2 XBI 10.18% 336,505 $41M $121.93 $799K -65,000 -16.2%
3 STXS 7.81% 13,680,554 $31M $2.30 -$11M
4 ATRC 5.86% 597,431 $24M $39.56 $3M +5,158 +0.9%
5 CYTK 5.85% 370,997 $24M $63.54 $2M -23,943 -6.1%
6 IDYA 4.35% 506,740 $18M $34.57 $3M -33,183 -6.2%
7 AXGN 3.87% 476,826 $16M $32.73 $2M -265,456 -35.8%
8 XENE 3.20% 287,939 $13M $44.82 $1M
9 IBB 2.85% 68,095 $11M $168.77 -$3M -34,405 -33.6%
10 RCUS 2.55% 431,329 $10M $23.83 $2M -196,297 -31.3%
11 NBIX 2.49% 70,615 $10M $141.83 $102K
12 DAWN 2.31% 999,163 $9M $9.32 $2M
13 TNDM 1.94% 355,208 $8M $21.98 $3M
14 DXCM 1.45% 88,279 $6M $66.37 $1M +22,727 +34.7%
15 SNDX 1.45% 277,855 $6M $21.01 -$2M -222,847 -44.5%
16 KALV 1.43% 356,802 $6M $16.15 $613K -65,929 -15.6%
17 CMPS 1.39% 811,046 $6M $6.90 $949K
18 INGN 1.38% 827,071 $6M $6.72 $610K +221,446 +36.6%
19 DNLI 1.30% 318,500 $5M $16.51 $3M +150,000 +89.0%
20 MBX 1.29% 165,265 $5M $31.54 $4M +80,265 +94.4%
21 BCAX 1.09% 261,583 $4M $16.83 -$603K -55,418 -17.5%
22 LKFT 1.06% 130,175 $4M $32.70 -$253K
23 ATXS 0.99% 304,775 $4M $13.09 $2M -15,000 -4.7%
24 EWTX 0.98% 159,736 $4M $24.82 $497K -54,000 -25.3%
25 IMVT 0.95% 150,524 $4M $25.42 $739K -40,969 -21.4%
26 PRCT 0.94% 120,000 $4M $31.46 +120,000 NEW
27 CYBN 0.92% 455,018 $4M $8.18 +455,018 NEW
28 ALKS 0.90% 130,248 $4M $27.98 -$398K -4,500 -3.3%
29 LRMR 0.89% 939,164 $4M $3.81 $259K -88,600 -8.6%
30 STOK 0.86% 108,875 $3M $31.74 -$534K -60,916 -35.9%
31 LXEO 0.84% 340,859 $3M $9.93 $1M -17,224 -4.8%
32 BCRX 0.81% 418,255 $3M $7.80 $2M +200,000 +91.6%
33 NKTR 0.79% 74,998 $3M $42.28 $42K +20,000 +36.4%
34 PRQR 0.79% 1,567,561 $3M $2.02 -$172K
35 IPSC 0.69% 2,793,586 $3M $0.99 $2M +1,089,354 +63.9%
36 IMTX 0.68% 261,138 $3M $10.50 $740K +26,138 +11.1%
37 GPCR 0.64% 37,000 $3M $69.55 $921K -22,000 -37.3%
38 MPLT 0.63% 143,764 $3M $17.57 +143,764 NEW
39 ALGN 0.62% 16,000 $2M $156.15 $1M +5,000 +45.5%
40 KURA 0.61% 235,868 $2M $10.39 -$2M -227,500 -49.1%
41 AQST 0.60% 375,915 $2M $6.46 -$437K -136,674 -26.7%
42 RAPP 0.56% 75,000 $2M $30.34 $48K
43 PROF 0.56% 285,710 $2M $7.87 +285,710 NEW
44 SPRY 0.55% 190,065 $2M $11.65 $802K +49,565 +35.3%
45 VKTX 0.52% 59,516 $2M $35.18 $398K -5,000 -7.8%
46 PODD 0.48% 6,870 $2M $284.24 -$168K
47 ALLO 0.47% 1,380,118 $2M $1.37 $179K
48 CLDX 0.46% 68,518 $2M $27.16 $1M +44,000 +179.5%
49 TELA 0.42% 1,441,029 $2M $1.18 -$447K
50 VRCA 0.36% 173,451 $1M $8.31 +173,451 NEW
51 ALEC 0.35% 908,351 $1M $1.56 -$946K +110,000 +13.8%
52 MLYS 0.35% 38,490 $1M $36.29 -$2M -45,000 -53.9%
53 ANNX 0.34% 272,812 $1M $5.02 +272,812 NEW
54 ORIC 0.29% 141,045 $1M $8.18 -$102K +36,374 +34.8%
55 ARAY 0.29% 1,395,508 $1M $0.82 -$891K +173,150 +14.2%
56 ERAS 0.23% 254,436 $947K $3.72 $184K -95,564 -27.3%
57 INSP 0.20% 8,600 $793K $92.23 -$483K -8,600 -50.0%
58 FHTX 0.17% 126,859 $685K $5.40 $65K
59 BNTX 0.17% 7,000 $666K $95.20 -$24K
60 NGNE 0.14% 27,974 $576K $20.60 $50K -2,401 -7.9%
61 FATE 0.13% 550,000 $540K $0.98 +550,000 NEW
62 OBIO 0.13% 126,841 $526K $4.15 -$375K -236,795 -65.1%
63 BCYC 0.11% 64,492 $457K $7.08 -$43K
64 CGEN 0.10% 272,402 $417K $1.53 $16K
65 KPTI 0.09% 51,000 $375K $7.36 +51,000 NEW
66 RARE 0.09% 16,000 $368K $23.00 +16,000 NEW
67 AUTL 0.09% 179,316 $357K $1.99 $65K
68 ADCT 0.07% 77,081 $272K $3.53 -$216K -45,000 -36.9%
69 BWAY 0.06% 12,965 $247K $19.02 -$612K -44,001 -77.2%
70 CATX 0.03% 50,000 $138K $2.75 +50,000 NEW
71 URGN —% -$549K -27,515 -100.0% SOLD
72 STRO —% -$380K -437,079 -100.0% SOLD
73 CMPX —% -$3M -946,661 -100.0% SOLD
74 KROS —% -$1M -80,716 -100.0% SOLD
75 BDTX —% -$1M -307,070 -100.0% SOLD
76 KRRO —% -$3M -60,804 -100.0% SOLD
77 MRUS —% -$21M -220,451 -100.0% SOLD

New Positions

SymbolValue% Port
PRCT $4M 0.94%
CYBN $4M 0.92%
MPLT $3M 0.63%
PROF $2M 0.56%
VRCA $1M 0.36%
ANNX $1M 0.34%
FATE $540K 0.13%
KPTI $375K 0.09%
RARE $368K 0.09%
CATX $138K 0.03%

Sold Out Positions

SymbolValue% Port
BDTX —%
KROS —%
KRRO —%
CMPX —%
URGN —%
STRO —%
MRUS —%
View SEC EDGAR Filings for DAFNA Capital Management LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms