Asset Manager
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SPHERA FUNDS MANAGEMENT LTD.
Market Value
$631M
+19.4%
Holdings
107
+2
New Purchases
22
Added To
31
Closed
16
Reduced
27
Top 10 Concentration
34.5%
Turnover
35.5%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| CYTK | 2.97% | 0.50% | +2.47% | $19M |
| INSM | 2.01% | 0.00% | +2.01% | $13M |
| BMRN | 2.98% | 1.50% | +1.48% | $19M |
| RYTM | 1.41% | 0.00% | +1.41% | $9M |
| LRCX | 1.27% | 0.00% | +1.27% | $8M |
| AMAT | 1.26% | 0.00% | +1.26% | $8M |
| IDYA | 1.16% | 0.00% | +1.16% | $7M |
| NVCT | 1.12% | 0.00% | +1.12% | $7M |
| HRMY | 1.02% | 0.00% | +1.02% | $6M |
| HELP | 1.70% | 0.90% | +0.80% | $11M |
| VST | 0.74% | 0.00% | +0.74% | $5M |
| TLN | 0.74% | 0.00% | +0.74% | $5M |
| CLOU | 0.71% | 0.00% | +0.71% | $4M |
| MAZE | 1.97% | 1.28% | +0.69% | $12M |
| AVTX | 0.68% | 0.00% | +0.68% | $4M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| NVMI | 2.17% | 4.38% | -2.22% | $14M |
| FOLD | 0.00% | 1.65% | -1.65% | $0 |
| CLBT | 0.00% | 1.65% | -1.65% | $0 |
| APLS | 0.00% | 1.64% | -1.64% | $0 |
| PANW | 0.00% | 1.60% | -1.60% | $0 |
| CAMT | 0.00% | 1.52% | -1.52% | $0 |
| SLNO | 0.00% | 1.37% | -1.37% | $0 |
| AMZN | 0.00% | 1.26% | -1.26% | $0 |
| AAOI | 0.00% | 1.17% | -1.17% | $0 |
| ENPH | 0.00% | 1.02% | -1.02% | $0 |
| ORA | 0.48% | 1.45% | -0.96% | $3M |
| BCRX | 0.67% | 1.56% | -0.89% | $4M |
| SNY | 1.82% | 2.46% | -0.63% | $11M |
| MLYS | 6.28% | 6.87% | -0.58% | $40M |
| BHVN | 0.39% | 0.95% | -0.56% | $2M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Mega Cap | 11 | $71M | 11.2% |
| Large Cap | 18 | $171M | 27.0% |
| Mid Cap | 28 | $166M | 26.3% |
| Small Cap | 30 | $174M | 27.6% |
| Micro Cap | 20 | $50M | 7.9% |
Portfolio Analytics
Avg Market Cap
$78.3B
Median Market Cap
$2.1B
Avg P/E
44.4
Median P/E
31.2
Avg Dividend Yield
0.01%
Avg Beta
0.91
# Stocks
105
# ETFs / Funds
2
Top Holdings (107 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MLYS | 6.28% | 1,469,971 | $40M | $26.98 | $3M | +130,000 | +9.7% | |
| 2 | TSEM | 4.47% | 108,265 | $28M | $260.64 | $3M | -37,470 | -25.7% | |
| 3 | SNDX | 3.51% | 1,014,606 | $22M | $21.86 | $5M | +290,043 | +40.0% | |
| 4 | BIIB | 3.31% | 96,626 | $21M | $216.06 | $4M | +4,100 | +4.4% | |
| 5 | RARE | 3.11% | 588,494 | $20M | $33.39 | $3M | -220,839 | -27.3% | |
| 6 | BMRN | 2.98% | 328,550 | $19M | $57.22 | $11M | +188,650 | +134.8% | |
| 7 | CYTK | 2.97% | 219,987 | $19M | $85.19 | $16M | +180,170 | +452.5% | |
| 8 | BBIO | 2.90% | 245,346 | $18M | $74.48 | $61K | +100 | +0.0% | |
| 9 | COGT | 2.82% | 459,340 | $18M | $38.70 | $2M | +43,000 | +10.3% | |
| 10 | NVMI | 2.17% | 25,169 | $14M | $542.94 | -$10M | -28,197 | -52.8% | |
| 11 | INSM | 2.01% | 118,800 | $13M | $106.62 | — | +118,800 | — | NEW |
| 12 | MAZE | 1.97% | 417,564 | $12M | $29.84 | $6M | +190,221 | +83.7% | |
| 13 | AZN | 1.88% | 62,530 | $12M | $189.62 | -$475K | — | — | |
| 14 | SNY | 1.82% | 269,515 | $11M | $42.66 | -$1M | — | — | |
| 15 | HELP | 1.70% | 1,620,753 | $11M | $6.61 | $6M | +633,663 | +64.2% | |
| 16 | LLY | 1.53% | 8,040 | $10M | $1,199.43 | $1M | -1,000 | -11.1% | |
| 17 | MDGL | 1.48% | 17,419 | $9M | $536.95 | $5M | +8,379 | +92.7% | |
| 18 | TRVI | 1.47% | 499,029 | $9M | $18.65 | $2M | -75,000 | -13.1% | |
| 19 | ACAD | 1.43% | 356,534 | $9M | $25.30 | $3M | +100,332 | +39.2% | |
| 20 | CLDX | 1.42% | 240,868 | $9M | $37.21 | $1M | -2,707 | -1.1% | |
| 21 | RYTM | 1.41% | 80,400 | $9M | $111.03 | — | +80,400 | — | NEW |
| 22 | ORIC | 1.29% | 752,983 | $8M | $10.83 | $1M | +215,355 | +40.1% | |
| 23 | LRCX | 1.27% | 18,470 | $8M | $433.33 | — | +18,470 | — | NEW |
| 24 | AMAT | 1.26% | 11,040 | $8M | $723.00 | — | +11,040 | — | NEW |
| 25 | TNGX | 1.26% | 254,250 | $8M | $31.26 | $761K | -89,313 | -26.0% | |
| 26 | NVS | 1.24% | 50,000 | $8M | $156.66 | $2M | +13,000 | +35.1% | |
| 27 | VOR | 1.21% | 416,417 | $8M | $18.41 | $2M | +94,500 | +29.4% | |
| 28 | ABBV | 1.21% | 30,256 | $8M | $251.64 | $1M | — | — | |
| 29 | MRK | 1.19% | 58,600 | $8M | $128.50 | $2M | +10,000 | +20.6% | |
| 30 | JNJ | 1.16% | 28,831 | $7M | $253.97 | $275K | — | — | |
| 31 | IDYA | 1.16% | 196,408 | $7M | $37.27 | — | +196,408 | — | NEW |
| 32 | IMTX | 1.16% | 720,057 | $7M | $10.13 | $445K | +23,952 | +3.4% | |
| 33 | NVCT | 1.12% | 382,945 | $7M | $18.39 | — | +382,945 | — | NEW |
| 34 | PFE | 1.09% | 286,000 | $7M | $24.08 | $2M | +100,000 | +53.8% | |
| 35 | HRMY | 1.02% | 176,663 | $6M | $36.41 | — | +176,663 | — | NEW |
| 36 | XENE | 1.00% | 105,000 | $6M | $60.36 | -$1M | -22,000 | -17.3% | |
| 37 | CLYM | 1.00% | 483,747 | $6M | $13.04 | $3M | +64,500 | +15.4% | |
| 38 | ZBIO | 0.93% | 230,834 | $6M | $25.38 | $2M | +16,500 | +7.7% | |
| 39 | NVO | 0.92% | 120,677 | $6M | $47.94 | $1M | — | — | |
| 40 | ELVN | 0.91% | 112,765 | $6M | $50.75 | -$285K | -40,500 | -26.4% | |
| 41 | PRLD | 0.86% | 1,019,832 | $5M | $5.33 | $4M | +461,493 | +82.7% | |
| 42 | GSK | 0.85% | 102,000 | $5M | $52.42 | -$1M | -20,000 | -16.4% | |
| 43 | FBRX | 0.84% | 249,693 | $5M | $21.25 | $515K | +64,709 | +35.0% | |
| 44 | BIOA | 0.83% | 213,671 | $5M | $24.51 | $4M | +127,153 | +147.0% | |
| 45 | SRRK | 0.82% | 94,265 | $5M | $55.00 | $551K | — | — | |
| 46 | MSLE | 0.80% | 652,590 | $5M | $7.77 | $2M | +163,383 | +33.4% | |
| 47 | PALI | 0.75% | 2,257,106 | $5M | $2.09 | $2M | +523,635 | +30.2% | |
| 48 | ELDN | 0.74% | 1,191,187 | $5M | $3.94 | -$765K | -580,944 | -32.8% | |
| 49 | VST | 0.74% | 29,450 | $5M | $158.63 | — | +29,450 | — | NEW |
| 50 | TLN | 0.74% | 12,135 | $5M | $384.26 | — | +12,135 | — | NEW |
| 51 | SVRA | 0.74% | 756,164 | $5M | $6.16 | $622K | +17,000 | +2.3% | |
| 52 | IRON | 0.74% | 63,538 | $5M | $73.14 | $1M | +10,000 | +18.7% | |
| 53 | CLOU | 0.71% | 195,900 | $4M | $22.74 | — | +195,900 | — | NEW |
| 54 | DYN | 0.70% | 199,594 | $4M | $22.21 | $2M | +39,000 | +24.3% | |
| 55 | RLAY | 0.69% | 233,836 | $4M | $18.71 | $311K | -174,600 | -42.8% | |
| 56 | AVTX | 0.68% | 232,294 | $4M | $18.48 | — | +232,294 | — | NEW |
| 57 | PMN | 0.68% | 325,591 | $4M | $13.16 | $150K | — | — | |
| 58 | BCRX | 0.67% | 422,051 | $4M | $10.00 | -$4M | -444,413 | -51.3% | |
| 59 | RVMD | 0.66% | 22,400 | $4M | $187.28 | -$1M | -32,710 | -59.4% | |
| 60 | CABA | 0.65% | 1,329,012 | $4M | $3.11 | — | +1,329,012 | — | NEW |
| 61 | GENB | 0.65% | 245,000 | $4M | $16.87 | $2M | +60,000 | +32.4% | |
| 62 | ACOG | 0.62% | 545,816 | $4M | $7.22 | $825K | -21,800 | -3.8% | |
| 63 | CRVS | 0.58% | 244,961 | $4M | $14.94 | $32K | -3,000 | -1.2% | |
| 64 | OVID | 0.58% | 1,353,000 | $4M | $2.69 | $37K | -269,828 | -16.6% | |
| 65 | BBOT | 0.56% | 460,985 | $4M | $7.62 | — | +460,985 | — | NEW |
| 66 | CTMX | 0.52% | 879,000 | $3M | $3.75 | $2M | +659,000 | +299.6% | |
| 67 | PRQR | 0.52% | 1,757,458 | $3M | $1.86 | — | +1,757,458 | — | NEW |
| 68 | ALNY | 0.52% | 10,800 | $3M | $301.03 | — | +10,800 | — | NEW |
| 69 | KURA | 0.51% | 295,039 | $3M | $10.97 | $834K | -483 | -0.2% | |
| 70 | KOD | 0.51% | 81,796 | $3M | $38.96 | -$1M | -33,000 | -28.8% | |
| 71 | ORA | 0.48% | 28,015 | $3M | $108.90 | -$5M | -40,235 | -59.0% | |
| 72 | CTNM | 0.48% | 183,475 | $3M | $16.39 | $742K | +10,000 | +5.8% | |
| 73 | LRMR | 0.45% | 926,004 | $3M | $3.05 | — | +926,004 | — | NEW |
| 74 | IMMX | 0.44% | 270,000 | $3M | $10.31 | — | +270,000 | — | NEW |
| 75 | AMGN | 0.43% | 7,500 | $3M | $362.12 | $77K | — | — | |
| 76 | BHVN | 0.39% | 164,437 | $2M | $14.88 | -$3M | -429,563 | -72.3% | |
| 77 | CEG | 0.39% | 9,850 | $2M | $248.37 | — | +9,850 | — | NEW |
| 78 | VSTM | 0.38% | 632,632 | $2M | $3.82 | $595K | +288,954 | +84.1% | |
| 79 | TENX | 0.28% | 120,200 | $2M | $14.55 | -$426K | -15,815 | -11.6% | |
| 80 | TSHA | 0.27% | 250,000 | $2M | $6.81 | — | +250,000 | — | NEW |
| 81 | GPCR | 0.24% | 28,600 | $2M | $53.67 | -$914K | -22,200 | -43.7% | |
| 82 | UPB | 0.24% | 219,700 | $2M | $6.92 | -$2M | -138,300 | -38.6% | |
| 83 | VYGR | 0.24% | 427,554 | $1M | $3.50 | -$317K | -42,207 | -9.0% | |
| 84 | ORGO | 0.21% | 550,000 | $1M | $2.43 | $33K | — | — | |
| 85 | IKT | 0.21% | 649,309 | $1M | $2.03 | — | +649,309 | — | NEW |
| 86 | STTK | 0.10% | 86,461 | $600K | $6.94 | -$1M | -194,325 | -69.2% | |
| 87 | TRAX | 0.09% | 27,876 | $561K | $20.12 | — | +27,876 | — | NEW |
| 88 | TRAW | 0.05% | 398,486 | $336K | $0.84 | — | +398,486 | — | NEW |
| 89 | EVMN | 0.05% | 22,632 | $301K | $13.29 | -$1M | -55,602 | -71.1% | |
| 90 | HOWL | 0.04% | 626,810 | $226K | $0.36 | -$296K | — | — | |
| 91 | APRE | 0.03% | 270,000 | $217K | $0.80 | $11K | — | — | |
| 92 | PANW | —% | — | — | — | -$8M | -52,800 | -100.0% | SOLD |
| 93 | IBIT | —% | — | — | — | -$2M | -59,505 | -100.0% | SOLD |
| 94 | NICE | —% | — | — | — | -$619K | -5,611 | -100.0% | SOLD |
| 95 | CAMT | —% | — | — | — | -$8M | -53,020 | -100.0% | SOLD |
| 96 | DTIL | —% | — | — | — | -$220K | -40,000 | -100.0% | SOLD |
| 97 | AAOI | —% | — | — | — | -$6M | -73,400 | -100.0% | SOLD |
| 98 | SEDG | —% | — | — | — | -$3M | -52,836 | -100.0% | SOLD |
| 99 | ZIM | —% | — | — | — | -$3M | -105,950 | -100.0% | SOLD |
| 100 | AMZN | —% | — | — | — | -$7M | -31,940 | -100.0% | SOLD |
Options Breakdown
7 Calls
$41M Call Value
2 Puts
$26M Put Value
0.64 P/C Ratio