Asset Manager
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SPHERA FUNDS MANAGEMENT LTD.
Market Value
$529M
+28.7%
Holdings
105
-8
New Purchases
19
Added To
26
Closed
20
Reduced
28
Top 10 Concentration
37.0%
Turnover
37.1%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| MLYS | 6.87% | 3.97% | +2.90% | $36M |
| AZN | 2.33% | 0.00% | +2.33% | $12M |
| CLBT | 1.65% | 0.00% | +1.65% | $9M |
| PANW | 1.60% | 0.00% | +1.60% | $8M |
| RARE | 3.21% | 1.68% | +1.52% | $17M |
| ORA | 1.45% | 0.00% | +1.45% | $8M |
| BBIO | 3.45% | 2.01% | +1.44% | $18M |
| XENE | 1.40% | 0.00% | +1.40% | $7M |
| TSEM | 4.84% | 3.50% | +1.34% | $26M |
| AMZN | 1.26% | 0.00% | +1.26% | $7M |
| AAOI | 1.17% | 0.00% | +1.17% | $6M |
| BHVN | 0.95% | 0.00% | +0.95% | $5M |
| ZBIO | 0.79% | 0.00% | +0.79% | $4M |
| RLAY | 0.77% | 0.00% | +0.77% | $4M |
| PMN | 0.78% | 0.02% | +0.76% | $4M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ANNX | 0.00% | 1.61% | -1.61% | $0 |
| DYN | 0.55% | 1.87% | -1.32% | $3M |
| ATXS | 0.00% | 1.13% | -1.13% | $0 |
| SVRA | 0.76% | 1.73% | -0.97% | $4M |
| AMD | 0.00% | 0.94% | -0.94% | $0 |
| CYTK | 0.50% | 1.42% | -0.92% | $3M |
| IMTX | 1.30% | 2.20% | -0.91% | $7M |
| SEDG | 0.51% | 1.38% | -0.87% | $3M |
| BIIB | 3.21% | 4.06% | -0.85% | $17M |
| TARA | 0.00% | 0.84% | -0.84% | $0 |
| AVGO | 0.00% | 0.82% | -0.82% | $0 |
| SRRK | 0.88% | 1.70% | -0.82% | $5M |
| LLY | 1.57% | 2.37% | -0.79% | $8M |
| ESLT | 0.00% | 0.75% | -0.75% | $0 |
| HELP | 0.90% | 1.64% | -0.75% | $5M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Mega Cap | 11 | $64M | 12.0% |
| Large Cap | 14 | $135M | 25.5% |
| Mid Cap | 28 | $183M | 34.7% |
| Small Cap | 28 | $114M | 21.5% |
| Micro Cap | 24 | $33M | 6.3% |
Portfolio Analytics
Avg Market Cap
$95.8B
Median Market Cap
$2.0B
Avg P/E
50.8
Median P/E
36.7
Avg Dividend Yield
0.01%
Avg Beta
0.92
# Stocks
104
# ETFs / Funds
1
Top Holdings (105 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MLYS | 6.87% | 1,339,971 | $36M | $27.09 | $20M | +890,968 | +198.4% | |
| 2 | TSEM | 4.84% | 145,735 | $26M | $175.48 | $11M | +23,222 | +18.9% | |
| 3 | NVMI | 4.38% | 53,366 | $23M | $434.28 | $7M | +5,520 | +11.5% | |
| 4 | BBIO | 3.45% | 245,246 | $18M | $74.26 | $10M | +137,500 | +127.6% | |
| 5 | BIIB | 3.21% | 92,526 | $17M | $183.33 | $290K | -2,212 | -2.3% | |
| 6 | RARE | 3.21% | 809,333 | $17M | $20.95 | $10M | +508,710 | +169.2% | |
| 7 | SNDX | 3.20% | 724,563 | $17M | $23.36 | $904K | -38,000 | -5.0% | |
| 8 | COGT | 3.03% | 416,340 | $16M | $38.49 | $3M | +37,840 | +10.0% | |
| 9 | SNY | 2.46% | 269,515 | $13M | $48.18 | $1M | +30,000 | +12.5% | |
| 10 | AZN | 2.33% | 62,530 | $12M | $197.22 | — | +62,530 | — | NEW |
| 11 | FOLD | 1.65% | 603,377 | $9M | $14.46 | -$650K | -55,000 | -8.3% | |
| 12 | CLBT | 1.65% | 631,521 | $9M | $13.78 | — | +631,521 | — | NEW |
| 13 | APLS | 1.64% | 214,914 | $9M | $40.23 | $2M | -36,047 | -14.4% | |
| 14 | PANW | 1.60% | 52,800 | $8M | $160.32 | — | +52,800 | — | NEW |
| 15 | LLY | 1.57% | 9,040 | $8M | $919.77 | -$1M | — | — | |
| 16 | BCRX | 1.56% | 866,464 | $8M | $9.52 | $2M | +28,575 | +3.4% | |
| 17 | CAMT | 1.52% | 53,020 | $8M | $151.61 | $4M | +13,522 | +34.2% | |
| 18 | BMRN | 1.50% | 139,900 | $8M | $56.49 | -$833K | -7,100 | -4.8% | |
| 19 | CLDX | 1.46% | 243,575 | $8M | $31.72 | $1M | +3,811 | +1.6% | |
| 20 | ORA | 1.45% | 68,250 | $8M | $111.92 | — | +68,250 | — | NEW |
| 21 | XENE | 1.40% | 127,000 | $7M | $58.15 | — | +127,000 | — | NEW |
| 22 | SLNO | 1.37% | 216,281 | $7M | $33.48 | $930K | +79,967 | +58.7% | |
| 23 | TNGX | 1.36% | 343,563 | $7M | $20.92 | $2M | -201,000 | -36.9% | |
| 24 | JNJ | 1.33% | 28,831 | $7M | $244.44 | -$368K | -7,000 | -19.5% | |
| 25 | IMTX | 1.30% | 696,105 | $7M | $9.84 | -$2M | -165,000 | -19.2% | |
| 26 | TRVI | 1.30% | 574,029 | $7M | $11.93 | -$645K | -24,505 | -4.1% | |
| 27 | ORIC | 1.29% | 537,628 | $7M | $12.67 | -$1M | -466,750 | -46.5% | |
| 28 | MAZE | 1.28% | 227,343 | $7M | $29.85 | $4M | +155,500 | +216.4% | |
| 29 | GSK | 1.27% | 122,000 | $7M | $55.19 | $750K | — | — | |
| 30 | AMZN | 1.26% | 31,940 | $7M | $208.27 | — | +31,940 | — | NEW |
| 31 | ABBV | 1.24% | 30,256 | $7M | $217.49 | $810K | +5,000 | +19.8% | |
| 32 | AAOI | 1.17% | 73,400 | $6M | $84.59 | — | +73,400 | — | NEW |
| 33 | ELVN | 1.14% | 153,265 | $6M | $39.20 | $3M | -73,500 | -32.4% | |
| 34 | MRK | 1.11% | 48,600 | $6M | $120.29 | $730K | — | — | |
| 35 | VOR | 1.09% | 321,917 | $6M | $17.84 | $375K | -88,500 | -21.6% | |
| 36 | ACAD | 1.08% | 256,202 | $6M | $22.26 | $35K | +44,000 | +20.7% | |
| 37 | NVS | 1.07% | 37,000 | $6M | $152.75 | $551K | — | — | |
| 38 | ELDN | 1.03% | 1,772,131 | $5M | $3.08 | $2M | -360,000 | -16.9% | |
| 39 | ENPH | 1.02% | 142,419 | $5M | $37.81 | -$592K | -44,081 | -23.6% | |
| 40 | RVMD | 1.01% | 55,110 | $5M | $97.25 | $1M | +2,610 | +5.0% | |
| 41 | PFE | 0.99% | 186,000 | $5M | $28.08 | $3M | +100,000 | +116.3% | |
| 42 | BHVN | 0.95% | 594,000 | $5M | $8.46 | — | +594,000 | — | NEW |
| 43 | FBRX | 0.91% | 184,984 | $5M | $25.90 | -$278K | -885 | -0.5% | |
| 44 | HELP | 0.90% | 987,090 | $5M | $4.80 | -$2M | +161,514 | +19.6% | |
| 45 | MDGL | 0.90% | 9,040 | $5M | $523.47 | $3M | +5,740 | +173.9% | |
| 46 | SRRK | 0.88% | 94,265 | $5M | $49.16 | -$2M | -64,000 | -40.4% | |
| 47 | NVO | 0.84% | 120,677 | $4M | $36.75 | -$1M | +5,000 | +4.3% | |
| 48 | KOD | 0.83% | 114,796 | $4M | $38.12 | -$531K | -60,704 | -34.6% | |
| 49 | ZBIO | 0.79% | 214,334 | $4M | $19.55 | — | +214,334 | — | NEW |
| 50 | PMN | 0.78% | 325,591 | $4M | $12.70 | $4M | +313,784 | +2657.6% | |
| 51 | RLAY | 0.77% | 408,436 | $4M | $9.95 | — | +408,436 | — | NEW |
| 52 | SVRA | 0.76% | 739,164 | $4M | $5.46 | -$3M | -439,000 | -37.3% | |
| 53 | CRVS | 0.69% | 247,961 | $4M | $14.63 | $488K | -159,748 | -39.2% | |
| 54 | OVID | 0.68% | 1,622,828 | $4M | $2.22 | — | +1,622,828 | — | NEW |
| 55 | IRON | 0.65% | 53,538 | $3M | $63.94 | — | +53,538 | — | NEW |
| 56 | UPB | 0.61% | 358,000 | $3M | $9.00 | — | +358,000 | — | NEW |
| 57 | ACOG | 0.59% | 567,616 | $3M | $5.49 | -$573K | — | — | |
| 58 | PALI | 0.57% | 1,733,471 | $3M | $1.75 | $3M | +1,549,371 | +841.6% | |
| 59 | DYN | 0.55% | 160,594 | $3M | $18.13 | -$5M | -232,300 | -59.1% | |
| 60 | CLYM | 0.54% | 419,247 | $3M | $6.85 | -$857K | -513,000 | -55.0% | |
| 61 | ZIM | 0.53% | 105,950 | $3M | $26.35 | -$96K | -30,055 | -22.1% | |
| 62 | MSLE | 0.52% | 489,207 | $3M | $5.63 | — | +489,207 | — | NEW |
| 63 | SEDG | 0.51% | 52,836 | $3M | $51.05 | -$3M | -143,700 | -73.1% | |
| 64 | AMGN | 0.50% | 7,500 | $3M | $351.85 | $184K | — | — | |
| 65 | CYTK | 0.50% | 39,817 | $3M | $65.91 | -$3M | -51,900 | -56.6% | |
| 66 | GPCR | 0.46% | 50,800 | $2M | $48.20 | -$403K | +9,800 | +23.9% | |
| 67 | KURA | 0.45% | 295,522 | $2M | $8.13 | -$668K | — | — | |
| 68 | GENB | 0.44% | 185,000 | $2M | $12.50 | — | +185,000 | — | NEW |
| 69 | IBIT | 0.43% | 59,505 | $2M | $38.42 | $794K | +29,450 | +98.0% | |
| 70 | CTNM | 0.43% | 173,475 | $2M | $13.06 | $283K | — | — | |
| 71 | TENX | 0.41% | 136,015 | $2M | $15.99 | -$143K | -54,096 | -28.4% | |
| 72 | PRLD | 0.36% | 558,339 | $2M | $3.42 | $2M | +435,587 | +354.9% | |
| 73 | VSTM | 0.34% | 343,678 | $2M | $5.30 | -$832K | — | — | |
| 74 | VYGR | 0.34% | 469,761 | $2M | $3.86 | $478K | +130,000 | +38.3% | |
| 75 | STTK | 0.34% | 280,786 | $2M | $6.43 | $1M | +85,574 | +43.8% | |
| 76 | EVMN | 0.34% | 78,234 | $2M | $22.99 | -$1M | -87,913 | -52.9% | |
| 77 | BIOA | 0.29% | 86,518 | $2M | $17.49 | -$2M | -156,517 | -64.4% | |
| 78 | ORGO | 0.25% | 550,000 | $1M | $2.37 | — | +550,000 | — | NEW |
| 79 | BMY | 0.20% | 17,500 | $1M | $60.65 | $117K | — | — | |
| 80 | CTMX | 0.20% | 220,000 | $1M | $4.70 | — | +220,000 | — | NEW |
| 81 | NICE | 0.12% | 5,611 | $619K | $110.26 | — | +5,611 | — | NEW |
| 82 | HOWL | 0.10% | 626,810 | $522K | $0.83 | $125K | — | — | |
| 83 | DTIL | 0.04% | 40,000 | $220K | $5.50 | -$1M | -356,116 | -89.9% | |
| 84 | APRE | 0.04% | 270,000 | $206K | $0.76 | -$24K | — | — | |
| 85 | FHTX | 0.01% | 12,224 | $58K | $4.78 | — | +12,224 | — | NEW |
| 86 | TSHA | —% | — | — | — | -$2M | -368,146 | -100.0% | SOLD |
| 87 | JSPR | —% | — | — | — | -$888K | -485,401 | -100.0% | SOLD |
| 88 | AVGO | —% | — | — | — | -$3M | -9,755 | -100.0% | SOLD |
| 89 | MREO | —% | — | — | — | -$106K | -255,400 | -100.0% | SOLD |
| 90 | ANNX | —% | — | — | — | -$7M | -1,316,212 | -100.0% | SOLD |
| 91 | OKUR | —% | — | — | — | -$175K | -60,454 | -100.0% | SOLD |
| 92 | CATX | —% | — | — | — | -$962K | -349,973 | -100.0% | SOLD |
| 93 | APLT | —% | — | — | — | -$5K | -50,000 | -100.0% | SOLD |
| 94 | TRDA | —% | — | — | — | -$1M | -110,942 | -100.0% | SOLD |
| 95 | JANX | —% | — | — | — | -$2M | -157,840 | -100.0% | SOLD |
| 96 | PEPG | —% | — | — | — | -$791K | -121,467 | -100.0% | SOLD |
| 97 | TNYA | —% | — | — | — | -$1M | -1,500,000 | -100.0% | SOLD |
| 98 | TARA | —% | — | — | — | -$3M | -650,000 | -100.0% | SOLD |
| 99 | VRNS | —% | — | — | — | -$2M | -52,500 | -100.0% | SOLD |
| 100 | NRIX | —% | — | — | — | -$2M | -124,000 | -100.0% | SOLD |
Options Breakdown
6 Calls
$23M Call Value
1 Puts
$26M Put Value
1.13 P/C Ratio