Asset Manager
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SPHERA FUNDS MANAGEMENT LTD.
Market Value
$411M
+13.5%
Holdings
113
New Purchases
22
Added To
30
Closed
27
Reduced
23
Top 10 Concentration
32.2%
Turnover
43.4%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| COGT | 3.27% | 0.39% | +2.88% | $13M |
| SNDX | 3.90% | 1.65% | +2.25% | $16M |
| BMRN | 2.13% | 0.00% | +2.13% | $9M |
| SRRK | 1.70% | 0.00% | +1.70% | $7M |
| MLYS | 3.97% | 2.30% | +1.66% | $16M |
| BCRX | 1.59% | 0.00% | +1.59% | $7M |
| BBIO | 2.01% | 0.58% | +1.42% | $8M |
| VOR | 1.31% | 0.00% | +1.31% | $5M |
| KOD | 1.19% | 0.00% | +1.19% | $5M |
| ENPH | 1.46% | 0.26% | +1.19% | $6M |
| TNGX | 1.17% | 0.00% | +1.17% | $5M |
| APLS | 1.54% | 0.40% | +1.14% | $6M |
| HELP | 1.64% | 0.60% | +1.04% | $7M |
| BIIB | 4.06% | 3.20% | +0.86% | $17M |
| TARA | 0.84% | 0.00% | +0.84% | $3M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| NICE | 0.00% | 6.30% | -6.30% | $0 |
| QQQ | 0.00% | 3.81% | -3.81% | $0 |
| TSEM | 3.50% | 6.23% | -2.73% | $14M |
| CDTX | 0.00% | 2.00% | -2.00% | $0 |
| CLBT | 0.00% | 1.53% | -1.53% | $0 |
| RAPP | 0.00% | 1.29% | -1.29% | $0 |
| RARE | 1.68% | 2.93% | -1.25% | $7M |
| IMVT | 0.00% | 1.14% | -1.14% | $0 |
| CYTK | 1.42% | 2.45% | -1.03% | $6M |
| RZLT | 0.00% | 0.95% | -0.95% | $0 |
| PRAX | 0.00% | 0.85% | -0.85% | $0 |
| AMZN | 0.00% | 0.83% | -0.83% | $0 |
| META | 0.00% | 0.80% | -0.80% | $0 |
| ORA | 0.00% | 0.77% | -0.77% | $0 |
| VRNS | 0.42% | 1.17% | -0.75% | $2M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Mega Cap | 11 | $43M | 10.4% |
| Large Cap | 15 | $101M | 24.6% |
| Mid Cap | 31 | $128M | 31.2% |
| Small Cap | 33 | $111M | 27.1% |
| Micro Cap | 23 | $27M | 6.7% |
Portfolio Analytics
Avg Market Cap
$105.6B
Median Market Cap
$2.0B
Avg P/E
49.2
Median P/E
34.8
Avg Dividend Yield
0.00%
Avg Beta
0.91
# Stocks
111
# ETFs / Funds
2
Top Holdings (113 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | BIIB | 4.06% | 94,738 | $17M | $175.99 | $5M | +12,000 | +14.5% | |
| 2 | MLYS | 3.97% | 449,003 | $16M | $36.29 | $8M | +229,093 | +104.2% | |
| 3 | SNDX | 3.90% | 762,563 | $16M | $21.01 | $10M | +374,847 | +96.7% | |
| 4 | NVMI | 3.83% | 47,846 | $16M | $328.39 | $2M | +3,950 | +9.0% | |
| 5 | TSEM | 3.50% | 122,513 | $14M | $117.42 | -$8M | -189,289 | -60.7% | |
| 6 | COGT | 3.27% | 378,500 | $13M | $35.52 | $12M | +279,974 | +284.2% | |
| 7 | SNY | 2.83% | 239,515 | $12M | $48.46 | $1M | +20,000 | +9.1% | |
| 8 | LLY | 2.37% | 9,040 | $10M | $1,074.68 | $2M | -1,000 | -10.0% | |
| 9 | FOLD | 2.28% | 658,377 | $9M | $14.24 | $2M | -332,765 | -33.6% | |
| 10 | IMTX | 2.20% | 861,105 | $9M | $10.50 | $4M | +278,000 | +47.7% | |
| 11 | BMRN | 2.13% | 147,000 | $9M | $59.43 | — | +147,000 | — | NEW |
| 12 | BBIO | 2.01% | 107,746 | $8M | $76.49 | $6M | +67,000 | +164.4% | |
| 13 | ORIC | 2.00% | 1,004,378 | $8M | $8.18 | $3M | +572,685 | +132.7% | |
| 14 | DYN | 1.87% | 392,894 | $8M | $19.56 | $2M | -33,624 | -7.9% | |
| 15 | TRVI | 1.82% | 598,534 | $7M | $12.52 | $2M | -45,423 | -7.0% | |
| 16 | JNJ | 1.81% | 35,831 | $7M | $206.95 | -$156K | -5,000 | -12.2% | |
| 17 | SVRA | 1.73% | 1,178,164 | $7M | $6.03 | $2M | -172,169 | -12.8% | |
| 18 | SRRK | 1.70% | 158,265 | $7M | $44.05 | — | +158,265 | — | NEW |
| 19 | RARE | 1.68% | 300,623 | $7M | $23.00 | -$4M | -51,935 | -14.7% | |
| 20 | HELP | 1.64% | 825,576 | $7M | $8.18 | $5M | +455,200 | +122.9% | |
| 21 | ANNX | 1.61% | 1,316,212 | $7M | $5.02 | $1M | -478,175 | -26.6% | |
| 22 | BCRX | 1.59% | 837,889 | $7M | $7.80 | — | +837,889 | — | NEW |
| 23 | CLDX | 1.59% | 239,764 | $7M | $27.16 | $1M | +32,000 | +15.4% | |
| 24 | SLNO | 1.54% | 136,314 | $6M | $46.30 | $3M | +94,708 | +227.6% | |
| 25 | APLS | 1.54% | 250,961 | $6M | $25.12 | $5M | +187,301 | +294.2% | |
| 26 | GSK | 1.46% | 122,000 | $6M | $49.04 | $717K | — | — | |
| 27 | ENPH | 1.46% | 186,500 | $6M | $32.05 | $5M | +159,800 | +598.5% | |
| 28 | NVO | 1.43% | 115,677 | $6M | $50.88 | $22K | +10,000 | +9.5% | |
| 29 | CYTK | 1.42% | 91,717 | $6M | $63.54 | -$3M | -69,800 | -43.2% | |
| 30 | ABBV | 1.41% | 25,256 | $6M | $228.49 | -$77K | — | — | |
| 31 | SEDG | 1.38% | 196,536 | $6M | $28.85 | $454K | +55,570 | +39.4% | |
| 32 | ACAD | 1.38% | 212,202 | $6M | $26.71 | $2M | +63,302 | +42.5% | |
| 33 | VOR | 1.31% | 410,417 | $5M | $13.08 | — | +410,417 | — | NEW |
| 34 | MRK | 1.25% | 48,600 | $5M | $105.26 | $1M | — | — | |
| 35 | NVS | 1.24% | 37,000 | $5M | $137.87 | $356K | — | — | |
| 36 | FBRX | 1.23% | 185,869 | $5M | $27.27 | -$2M | -288,440 | -60.8% | |
| 37 | KOD | 1.19% | 175,500 | $5M | $27.96 | — | +175,500 | — | NEW |
| 38 | TNGX | 1.17% | 544,563 | $5M | $8.86 | — | +544,563 | — | NEW |
| 39 | ATXS | 1.13% | 355,725 | $5M | $13.09 | $3M | +104,500 | +41.6% | |
| 40 | CAMT | 1.02% | 39,498 | $4M | $106.35 | $1M | +10,450 | +36.0% | |
| 41 | RVMD | 1.02% | 52,500 | $4M | $79.65 | $1M | -7,500 | -12.5% | |
| 42 | AMD | 0.94% | 18,040 | $4M | $214.16 | $1M | +2,570 | +16.6% | |
| 43 | CLYM | 0.91% | 932,247 | $4M | $4.00 | $3M | +497,410 | +114.4% | |
| 44 | ACOG | 0.90% | 567,616 | $4M | $6.50 | $1M | +228,864 | +67.6% | |
| 45 | ELVN | 0.85% | 226,765 | $3M | $15.40 | $79K | +60,000 | +36.0% | |
| 46 | TARA | 0.84% | 650,000 | $3M | $5.33 | — | +650,000 | — | NEW |
| 47 | AVGO | 0.82% | 9,755 | $3M | $346.10 | $1M | +3,200 | +48.8% | |
| 48 | ELDN | 0.78% | 2,132,131 | $3M | $1.51 | -$96K | +851,898 | +66.5% | |
| 49 | BIOA | 0.78% | 243,035 | $3M | $13.23 | — | +243,035 | — | NEW |
| 50 | CRVS | 0.76% | 407,709 | $3M | $7.70 | $135K | — | — | |
| 51 | ESLT | 0.75% | 5,340 | $3M | $577.71 | -$351K | -1,400 | -20.8% | |
| 52 | KURA | 0.75% | 295,522 | $3M | $10.39 | $898K | +50,000 | +20.4% | |
| 53 | MAZE | 0.72% | 71,843 | $3M | $41.43 | -$1M | -82,500 | -53.5% | |
| 54 | ZIM | 0.70% | 136,005 | $3M | $21.23 | — | +136,005 | — | NEW |
| 55 | GPCR | 0.69% | 41,000 | $3M | $69.55 | -$2M | -132,931 | -76.4% | |
| 56 | EVMN | 0.69% | 166,147 | $3M | $17.12 | — | +166,147 | — | NEW |
| 57 | VSTM | 0.65% | 343,678 | $3M | $7.72 | $2M | +265,371 | +338.9% | |
| 58 | AMGN | 0.60% | 7,500 | $2M | $327.31 | -$226K | -2,000 | -21.1% | |
| 59 | NRIX | 0.57% | 124,000 | $2M | $18.97 | — | +124,000 | — | NEW |
| 60 | TENX | 0.56% | 190,111 | $2M | $12.19 | — | +190,111 | — | NEW |
| 61 | JANX | 0.53% | 157,840 | $2M | $13.80 | $80K | +72,000 | +83.9% | |
| 62 | PFE | 0.52% | 86,000 | $2M | $24.90 | -$50K | — | — | |
| 63 | TSHA | 0.49% | 368,146 | $2M | $5.50 | $690K | -40,000 | -9.8% | |
| 64 | CTNM | 0.48% | 173,475 | $2M | $11.43 | — | +173,475 | — | NEW |
| 65 | MDGL | 0.47% | 3,300 | $2M | $582.34 | — | +3,300 | — | NEW |
| 66 | VRNS | 0.42% | 52,500 | $2M | $32.80 | -$3M | -21,400 | -29.0% | |
| 67 | DTIL | 0.40% | 396,116 | $2M | $4.16 | — | +396,116 | — | NEW |
| 68 | VTYX | 0.40% | 180,114 | $2M | $9.03 | $258K | -260,000 | -59.1% | |
| 69 | IBIT | 0.36% | 30,055 | $1M | $49.65 | $98K | +8,600 | +40.1% | |
| 70 | DAWN | 0.33% | 145,371 | $1M | $9.32 | $118K | -30,000 | -17.1% | |
| 71 | VYGR | 0.33% | 339,761 | $1M | $3.93 | $402K | +140,000 | +70.1% | |
| 72 | TRDA | 0.28% | 110,942 | $1M | $10.28 | — | +110,942 | — | NEW |
| 73 | TNYA | 0.26% | 1,500,000 | $1M | $0.71 | — | +1,500,000 | — | NEW |
| 74 | CATX | 0.23% | 349,973 | $962K | $2.75 | -$788K | -160,370 | -31.4% | |
| 75 | BMY | 0.23% | 17,500 | $944K | $53.94 | $155K | — | — | |
| 76 | JSPR | 0.22% | 485,401 | $888K | $1.83 | -$610K | -144,069 | -22.9% | |
| 77 | PEPG | 0.19% | 121,467 | $791K | $6.51 | -$1K | -50,000 | -29.2% | |
| 78 | STTK | 0.17% | 195,212 | $713K | $3.65 | — | +195,212 | — | NEW |
| 79 | PALI | 0.11% | 184,100 | $433K | $2.35 | — | +184,100 | — | NEW |
| 80 | HOWL | 0.10% | 626,810 | $397K | $0.63 | -$838K | — | — | |
| 81 | PRLD | 0.09% | 122,752 | $356K | $2.90 | — | +122,752 | — | NEW |
| 82 | APRE | 0.06% | 270,000 | $230K | $0.85 | -$168K | — | — | |
| 83 | OKUR | 0.04% | 60,454 | $175K | $2.90 | $9K | — | — | |
| 84 | MREO | 0.03% | 255,400 | $106K | $0.42 | — | +255,400 | — | NEW |
| 85 | PMN | 0.02% | 11,807 | $81K | $6.83 | — | +11,807 | — | NEW |
| 86 | APLT | —% | 50,000 | $5K | $0.10 | -$25K | — | — | |
| 87 | CMMB | —% | — | — | — | -$472K | -179,425 | -100.0% | SOLD |
| 88 | ROIV | —% | — | — | — | -$644K | -42,571 | -100.0% | SOLD |
| 89 | RAPP | —% | — | — | — | -$5M | -157,533 | -100.0% | SOLD |
| 90 | PCVX | —% | — | — | — | -$2M | -50,000 | -100.0% | SOLD |
| 91 | NICE | —% | — | — | — | -$23M | -157,400 | -100.0% | SOLD |
| 92 | MIST | —% | — | — | — | -$2M | -820,000 | -100.0% | SOLD |
| 93 | RZLT | —% | — | — | — | -$3M | -363,947 | -100.0% | SOLD |
| 94 | LRMR | —% | — | — | — | -$841K | -260,385 | -100.0% | SOLD |
| 95 | MLTX | —% | — | — | — | -$509K | -71,010 | -100.0% | SOLD |
| 96 | IMNM | —% | — | — | — | -$2M | -147,200 | -100.0% | SOLD |
| 97 | QQQ | —% | — | — | — | -$14M | -22,960 | -100.0% | SOLD |
| 98 | SABS | —% | — | — | — | -$1M | -566,395 | -100.0% | SOLD |
| 99 | AMZN | —% | — | — | — | -$3M | -13,760 | -100.0% | SOLD |
| 100 | TECX | —% | — | — | — | -$2M | -115,908 | -100.0% | SOLD |
Options Breakdown
13 Calls
$30M Call Value
2 Puts
$9M Put Value
0.28 P/C Ratio