Asset Manager
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SPHERA FUNDS MANAGEMENT LTD.
Market Value
$362M
+10.0%
Holdings
113
-7
New Purchases
20
Added To
21
Closed
22
Reduced
30
Top 10 Concentration
36.1%
Turnover
37.2%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| NICE | 6.30% | 0.00% | +6.30% | $23M |
| QQQ | 3.81% | 0.00% | +3.81% | $14M |
| TSEM | 6.23% | 3.49% | +2.74% | $23M |
| RARE | 2.93% | 1.11% | +1.82% | $11M |
| CLBT | 1.53% | 0.00% | +1.53% | $6M |
| RAPP | 1.29% | 0.00% | +1.29% | $5M |
| VRNS | 1.17% | 0.00% | +1.17% | $4M |
| DYN | 1.49% | 0.64% | +0.85% | $5M |
| SLNO | 0.78% | 0.00% | +0.78% | $3M |
| RVMD | 0.77% | 0.00% | +0.77% | $3M |
| IDYA | 0.75% | 0.00% | +0.75% | $3M |
| GPCR | 1.35% | 0.60% | +0.74% | $5M |
| SEDG | 1.44% | 0.79% | +0.65% | $5M |
| CRVS | 0.83% | 0.22% | +0.61% | $3M |
| AVGO | 0.60% | 0.00% | +0.60% | $2M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| SNDX | 1.65% | 4.47% | -2.83% | $6M |
| NVDA | 0.00% | 2.62% | -2.62% | $0 |
| NVMI | 3.88% | 6.34% | -2.47% | $14M |
| MSFT | 0.00% | 1.78% | -1.78% | $0 |
| TVTX | 0.00% | 1.51% | -1.51% | $0 |
| AMZN | 0.83% | 2.16% | -1.33% | $3M |
| ORA | 0.77% | 1.99% | -1.21% | $3M |
| META | 0.80% | 1.91% | -1.12% | $3M |
| CLDX | 1.49% | 2.60% | -1.11% | $5M |
| RNAM | 0.00% | 1.09% | -1.09% | $0 |
| AMAT | 0.00% | 1.00% | -1.00% | $0 |
| ARWR | 0.12% | 0.97% | -0.86% | $431K |
| UBER | 0.00% | 0.85% | -0.85% | $0 |
| CYTK | 2.45% | 3.28% | -0.83% | $9M |
| SRPT | 0.00% | 0.83% | -0.83% | $0 |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Mega Cap | 16 | $57M | 15.7% |
| Large Cap | 17 | $83M | 22.9% |
| Mid Cap | 30 | $114M | 31.5% |
| Small Cap | 35 | $94M | 26.0% |
| Micro Cap | 15 | $14M | 3.8% |
Portfolio Analytics
Avg Market Cap
$201.6B
Median Market Cap
$2.8B
Avg P/E
44.8
Median P/E
32.8
Avg Dividend Yield
0.00%
Avg Beta
0.96
# Stocks
111
# ETFs / Funds
2
Top Holdings (113 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | NICE | 6.30% | 157,400 | $23M | $144.78 | — | +157,400 | — | NEW |
| 2 | TSEM | 6.23% | 311,802 | $23M | $72.30 | $11M | +47,080 | +17.8% | |
| 3 | NVMI | 3.88% | 43,896 | $14M | $319.66 | -$7M | -31,940 | -42.1% | |
| 4 | QQQ | 3.81% | 22,960 | $14M | $600.37 | — | +22,960 | — | NEW |
| 5 | BIIB | 3.20% | 82,738 | $12M | $140.08 | $1M | — | — | |
| 6 | RARE | 2.93% | 352,558 | $11M | $30.08 | $7M | +252,473 | +252.3% | |
| 7 | SNY | 2.86% | 219,515 | $10M | $47.20 | -$244K | — | — | |
| 8 | CYTK | 2.45% | 161,517 | $9M | $54.96 | -$2M | -165,201 | -50.6% | |
| 9 | MLYS | 2.30% | 219,910 | $8M | $37.92 | $2M | -261,064 | -54.3% | |
| 10 | FOLD | 2.16% | 991,142 | $8M | $7.88 | $2M | +424 | +0.0% | |
| 11 | LLY | 2.12% | 10,040 | $8M | $763.00 | -$1M | -1,500 | -13.0% | |
| 12 | JNJ | 2.09% | 40,831 | $8M | $185.42 | $1M | — | — | |
| 13 | CDTX | 2.00% | 75,743 | $7M | $95.76 | $531K | -62,258 | -45.1% | |
| 14 | FBRX | 1.97% | 474,309 | $7M | $15.00 | $713K | -20,800 | -4.2% | |
| 15 | SNDX | 1.65% | 387,716 | $6M | $15.39 | -$9M | -1,183,848 | -75.3% | |
| 16 | TRVI | 1.63% | 643,957 | $6M | $9.15 | $2M | -156,000 | -19.5% | |
| 17 | NVO | 1.62% | 105,677 | $6M | $55.49 | -$1M | — | — | |
| 18 | ABBV | 1.62% | 25,256 | $6M | $231.54 | $1M | — | — | |
| 19 | CLBT | 1.53% | 298,948 | $6M | $18.53 | — | +298,948 | — | NEW |
| 20 | ANNX | 1.51% | 1,794,387 | $5M | $3.05 | $1M | +30,000 | +1.7% | |
| 21 | DYN | 1.49% | 426,518 | $5M | $12.65 | $3M | +205,102 | +92.6% | |
| 22 | CLDX | 1.49% | 207,764 | $5M | $25.87 | -$3M | -211,776 | -50.5% | |
| 23 | GSK | 1.46% | 122,000 | $5M | $43.16 | $581K | — | — | |
| 24 | SEDG | 1.44% | 140,966 | $5M | $37.00 | $3M | +13,000 | +10.2% | |
| 25 | ORIC | 1.43% | 431,693 | $5M | $12.00 | $1M | +37,000 | +9.4% | |
| 26 | IMTX | 1.37% | 583,105 | $5M | $8.52 | $2M | — | — | |
| 27 | GPCR | 1.35% | 173,931 | $5M | $28.00 | $3M | +78,000 | +81.3% | |
| 28 | SVRA | 1.33% | 1,350,333 | $5M | $3.57 | $2M | +40,100 | +3.1% | |
| 29 | NVS | 1.31% | 37,000 | $5M | $128.24 | $268K | — | — | |
| 30 | RAPP | 1.29% | 157,533 | $5M | $29.70 | — | +157,533 | — | NEW |
| 31 | VRNS | 1.17% | 73,900 | $4M | $57.47 | — | +73,900 | — | NEW |
| 32 | IMVT | 1.14% | 256,743 | $4M | $16.12 | $31K | — | — | |
| 33 | MRK | 1.13% | 48,600 | $4M | $83.93 | $232K | — | — | |
| 34 | MAZE | 1.11% | 154,343 | $4M | $25.93 | -$372K | -202,110 | -56.7% | |
| 35 | ESLT | 0.95% | 6,740 | $3M | $509.80 | $739K | +740 | +12.3% | |
| 36 | RZLT | 0.95% | 363,947 | $3M | $9.40 | $70K | -387,500 | -51.6% | |
| 37 | ELVN | 0.94% | 166,765 | $3M | $20.47 | $836K | +38,250 | +29.8% | |
| 38 | ELDN | 0.92% | 1,280,233 | $3M | $2.59 | -$2M | -679,377 | -34.7% | |
| 39 | ACAD | 0.88% | 148,900 | $3M | $21.34 | -$595K | -26,000 | -14.9% | |
| 40 | PRAX | 0.85% | 57,901 | $3M | $53.00 | -$2M | -51,856 | -47.2% | |
| 41 | CAMT | 0.84% | 29,048 | $3M | $105.05 | $348K | -2,928 | -9.2% | |
| 42 | AMZN | 0.83% | 13,760 | $3M | $219.57 | -$4M | -18,681 | -57.6% | |
| 43 | CRVS | 0.83% | 407,709 | $3M | $7.37 | $2M | +224,615 | +122.7% | |
| 44 | META | 0.80% | 3,924 | $3M | $734.38 | -$3M | -4,602 | -54.0% | |
| 45 | SLNO | 0.78% | 41,606 | $3M | $67.60 | — | +41,606 | — | NEW |
| 46 | RVMD | 0.77% | 60,000 | $3M | $46.70 | — | +60,000 | — | NEW |
| 47 | ORA | 0.77% | 29,000 | $3M | $96.25 | -$4M | -49,000 | -62.8% | |
| 48 | IDYA | 0.75% | 100,000 | $3M | $27.21 | — | +100,000 | — | NEW |
| 49 | AMGN | 0.74% | 9,500 | $3M | $282.20 | $28K | — | — | |
| 50 | AMD | 0.69% | 15,470 | $3M | $161.79 | $1M | +7,220 | +87.5% | |
| 51 | ACOG | 0.61% | 338,752 | $2M | $6.51 | -$1M | -37,897 | -10.1% | |
| 52 | PFE | 0.61% | 86,000 | $2M | $25.48 | $107K | — | — | |
| 53 | HELP | 0.60% | 370,376 | $2M | $5.89 | -$1M | -27,933 | -7.0% | |
| 54 | KURA | 0.60% | 245,522 | $2M | $8.85 | $814K | +10,000 | +4.2% | |
| 55 | AVGO | 0.60% | 6,555 | $2M | $329.91 | — | +6,555 | — | NEW |
| 56 | CEVA | 0.59% | 81,085 | $2M | $26.41 | $1M | +32,165 | +65.8% | |
| 57 | BBIO | 0.58% | 40,746 | $2M | $51.94 | -$2M | -46,362 | -53.2% | |
| 58 | JANX | 0.58% | 85,840 | $2M | $24.44 | $115K | — | — | |
| 59 | ATXS | 0.51% | 251,225 | $2M | $7.28 | $449K | -6,177 | -2.4% | |
| 60 | TECX | 0.50% | 115,908 | $2M | $15.69 | — | +115,908 | — | NEW |
| 61 | PCVX | 0.50% | 50,000 | $2M | $36.02 | — | +50,000 | — | NEW |
| 62 | CATX | 0.48% | 510,343 | $2M | $3.43 | $683K | +200,000 | +64.4% | |
| 63 | IMNM | 0.48% | 147,200 | $2M | $11.71 | — | +147,200 | — | NEW |
| 64 | MIST | 0.45% | 820,000 | $2M | $2.00 | — | +820,000 | — | NEW |
| 65 | JSPR | 0.41% | 629,470 | $1M | $2.38 | $1M | +614,799 | +4190.6% | |
| 66 | APLS | 0.40% | 63,660 | $1M | $22.63 | -$539K | -50,686 | -44.3% | |
| 67 | COGT | 0.39% | 98,526 | $1M | $14.36 | $383K | -45,167 | -31.4% | |
| 68 | IBIT | 0.39% | 21,455 | $1M | $65.00 | $81K | — | — | |
| 69 | VTYX | 0.38% | 440,114 | $1M | $3.11 | $179K | -115,700 | -20.8% | |
| 70 | BHVN | 0.38% | 91,155 | $1M | $15.01 | -$683K | -54,217 | -37.3% | |
| 71 | BCAX | 0.37% | 85,747 | $1M | $15.79 | $744K | +20,068 | +30.6% | |
| 72 | TSHA | 0.37% | 408,146 | $1M | $3.27 | $364K | -11,854 | -2.8% | |
| 73 | DAWN | 0.34% | 175,371 | $1M | $7.05 | $96K | — | — | |
| 74 | HOWL | 0.34% | 626,810 | $1M | $1.97 | $552K | — | — | |
| 75 | SABS | 0.31% | 566,395 | $1M | $2.01 | — | +566,395 | — | NEW |
| 76 | ENPH | 0.26% | 26,700 | $945K | $35.39 | — | +26,700 | — | NEW |
| 77 | VYGR | 0.26% | 199,761 | $933K | $4.67 | — | +199,761 | — | NEW |
| 78 | CLYM | 0.24% | 434,837 | $874K | $2.01 | $614K | +225,000 | +107.2% | |
| 79 | LRMR | 0.23% | 260,385 | $841K | $3.23 | $273K | +63,750 | +32.4% | |
| 80 | PEPG | 0.22% | 171,467 | $792K | $4.62 | $618K | +15,000 | +9.6% | |
| 81 | BMY | 0.22% | 17,500 | $789K | $45.10 | -$21K | — | — | |
| 82 | VSTM | 0.19% | 78,307 | $691K | $8.83 | $14K | -85,000 | -52.0% | |
| 83 | ROIV | 0.18% | 42,571 | $644K | $15.13 | — | +42,571 | — | NEW |
| 84 | ETNB | 0.16% | 39,675 | $583K | $14.70 | -$1M | -166,000 | -80.7% | |
| 85 | MLTX | 0.14% | 71,010 | $509K | $7.17 | — | +71,010 | — | NEW |
| 86 | CMMB | 0.13% | 179,425 | $472K | $2.63 | — | +179,425 | — | NEW |
| 87 | ARWR | 0.12% | 12,496 | $431K | $34.49 | -$3M | -190,500 | -93.8% | |
| 88 | APRE | 0.11% | 270,000 | $398K | $1.48 | -$58K | — | — | |
| 89 | OKUR | 0.05% | 60,454 | $166K | $2.75 | $22K | — | — | |
| 90 | DSGN | 0.05% | 21,918 | $165K | $7.53 | — | +21,918 | — | NEW |
| 91 | APLT | 0.01% | 50,000 | $30K | $0.60 | $15K | — | — | |
| 92 | SRRK | —% | — | — | — | -$2M | -57,497 | -100.0% | SOLD |
| 93 | SLDB | —% | — | — | — | -$244K | -50,190 | -100.0% | SOLD |
| 94 | CGNT | —% | — | — | — | -$417K | -45,181 | -100.0% | SOLD |
| 95 | NVDA | —% | — | — | — | -$9M | -54,515 | -100.0% | SOLD |
| 96 | NTLA | —% | — | — | — | -$1M | -128,780 | -100.0% | SOLD |
| 97 | TVTX | —% | — | — | — | -$5M | -335,333 | -100.0% | SOLD |
| 98 | MRVL | —% | — | — | — | -$1M | -18,730 | -100.0% | SOLD |
| 99 | NNDM | —% | — | — | — | -$1M | -717,518 | -100.0% | SOLD |
| 100 | S | —% | — | — | — | -$494K | -27,000 | -100.0% | SOLD |
Options Breakdown
14 Calls
$48M Call Value
3 Puts
$518K Put Value
0.01 P/C Ratio