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SYRE NASDAQ

Spyre Therapeutics, Inc.
1W: -1.8% 1M: +1.8% 3M: +72.0% YTD: +143.0% 1Y: +382.6% 3Y: +1892.5% 5Y: -60.7%
$74.05
-0.27 (-0.36%)
 
Weekly Expected Move ±7.0%
$64 $70 $75 $80 $85
NASDAQ · Healthcare · Biotechnology · Alpha Radar Buy · Power 55 · $4.5B mcap · 53M float · 2.10% daily turnover · Short 64% of daily vol

🏦 Institutional Activity

Latest: Q1 2026
202
Institutions Holding
+35 vs prior
78.9%
Ownership
+14.24%
49 New
60 Increased
70 Reduced
31 Closed

👔 Insider Trades

25 records
Date Name Title Type Shares Price Value Filing
2026-05-08 HENDERSON MICHAEL THOMAS director S-Sale 19,269 $75.35 $1.5M Filing
2026-05-08 HENDERSON MICHAEL THOMAS director S-Sale 24,814 $74.76 $1.9M Filing
2026-05-08 HENDERSON MICHAEL THOMAS director S-Sale 33,513 $73.72 $2.5M Filing
2026-05-08 HENDERSON MICHAEL THOMAS director S-Sale 2,404 $72.57 $174K Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 10,358 $73.74 $764K Filing
2026-05-01 Burrows Scott L officer: chief financial officer S-Sale 12,500 $71.37 $892K Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 21,306 $69.53 $1.5M Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 19,656 $70.61 $1.4M Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 8,777 $71.56 $628K Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 12,777 $72.94 $932K Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 5,059 $74.60 $377K Filing
2026-05-01 Sloan Sheldon officer: chief medical officer S-Sale 400 $75.37 $30K Filing
2026-05-01 Turtle Cameron officer: chief executive officer S-Sale 5,300 $69.54 $369K Filing
2026-05-01 Turtle Cameron officer: chief executive officer S-Sale 3,600 $70.77 $255K Filing
2026-05-01 Turtle Cameron officer: chief executive officer S-Sale 1,000 $71.76 $72K Filing
2026-05-01 Turtle Cameron officer: chief executive officer S-Sale 3,100 $73.14 $227K Filing
2026-05-01 Turtle Cameron officer: chief executive officer S-Sale 1,700 $74.23 $126K Filing
2026-05-01 Turtle Cameron officer: chief executive officer S-Sale 300 $74.96 $22K Filing
2026-04-01 Turtle Cameron officer: chief executive officer S-Sale 12,344 $49.20 $607K Filing
2026-04-01 Turtle Cameron officer: chief executive officer S-Sale 2,656 $49.92 $133K Filing
2026-04-01 Sloan Sheldon officer: chief medical officer S-Sale 7,958 $50.00 $398K Filing
2026-04-01 Burrows Scott L officer: chief financial officer S-Sale 1,300 $49.98 $65K Filing
2026-04-01 Burrows Scott L officer: chief financial officer S-Sale 6,200 $49.21 $305K Filing
2026-03-03 Burrows Scott L officer: chief financial officer S-Sale 200 $41.66 $8K Filing
2026-03-03 Burrows Scott L officer: chief financial officer S-Sale 2,300 $40.56 $93K Filing

🏛️ Congressional Trades

0 records
Date Politician Chamber Type Amount Filing
No congressional trades found

🏦 Top Institutional Holders

20 holders
Holder Shares Value Date Reported Filing
FMR LLC 11,781,024 $594M +142,205 2026-03-31 Filing
BlackRock, Inc. 5,521,221 $278M -880 2026-03-31 Filing
RTW INVESTMENTS, LP 4,171,996 $210M 2026-03-31 Filing
Fairmount Funds Management LLC 4,018,101 $203M 2026-03-31 Filing
VANGUARD CAPITAL MANAGEMENT LLC 3,057,401 $154M +3,057,401 2026-03-31 Filing
Driehaus Capital Management LLC 2,790,785 $141M -91,635 2026-03-31 Filing
STATE STREET CORP 2,607,031 $131M +344,192 2026-03-31 Filing
Paradigm Biocapital Advisors LP 1,957,266 $99M +490,000 2026-03-31 Filing
Commodore Capital LP 1,912,380 $96M -475,865 2026-03-31 Filing
TCG Crossover Management, LLC 1,900,582 $96M 2026-03-31 Filing
TANG CAPITAL MANAGEMENT LLC 1,892,200 $95M 2026-03-31 Filing
WELLINGTON MANAGEMENT GROUP LLP 1,824,811 $92M +275,527 2026-03-31 Filing
Capital International Investors 1,746,129 $88M -1,746,412 2026-03-31 Filing
GEODE CAPITAL MANAGEMENT, LLC 1,720,912 $87M +61,772 2026-03-31 Filing
JANUS HENDERSON GROUP PLC 1,656,164 $84M -172,845 2026-03-31 Filing
RA CAPITAL MANAGEMENT, L.P. 1,621,620 $82M 2026-03-31 Filing
Remedium Capital Partners, LLC 1,456,231 $73M 2026-03-31 Filing
Affinity Asset Advisors, LLC 1,279,134 $65M -153,457 2026-03-31 Filing
BANK OF AMERICA CORP /DE 1,228,093 $62M +808,366 2026-03-31 Filing
FRANKLIN RESOURCES INC 882,833 $45M -226,441 2026-03-31 Filing

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms