SYRE NASDAQ
Spyre Therapeutics, Inc.
1W: -1.8%
1M: +1.8%
3M: +72.0%
YTD: +143.0%
1Y: +382.6%
3Y: +1892.5%
5Y: -60.7%
$74.05
-0.27 (-0.36%)
Weekly Expected Move ±7.0%
$64
$70
$75
$80
$85
Overview
News
Chart
Smart Money
Financials
Income Statement
Cash Flow
Balance Sheet
Earnings
Dividends
Analysis
Technicals
Weather
Peers
ESG
Institutions
ETF Exposure
Dark Pool
Short Interest
Supply Chain
Institutional Ownership — SYRE
202
Institutional Holders
+35 vs prior quarter
0.0%
Ownership
+0.00pp
$4B
Total Invested
49
New Positions
60
Increased
70
Reduced
31
Closed
1.00
Put/Call Ratio
Ownership Trends
Top Institutional Holders (224 total)
| # | Holder | Shares | Value | Change | Change % | Holding Period | Filing |
|---|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,781,024 | $$872M | +142,205 | +1.2% | 10Q | SEC ↗ |
| 2 | VANGUARD CAPITAL MANAGEMENT LLC NEW | 6,114,802 | $$453M | — | +0.0% | 1Q | SEC ↗ |
| 3 | BlackRock, Inc. | 5,521,221 | $$409M | -880 | -0.0% | 7Q | SEC ↗ |
| 4 | RTW INVESTMENTS, LP | 4,171,996 | $$309M | — | +0.0% | 10Q | SEC ↗ |
| 5 | VANGUARD GROUP INC | 4,035,074 | $$299M | +984,344 | +32.3% | 10Q | SEC ↗ |
| 6 | Fairmount Funds Management LLC | 4,018,101 | $$298M | — | +0.0% | 11Q | SEC ↗ |
| 7 | VR ADVISER, LLC | 3,685,448 | $$273M | +1,000,000 | +37.2% | 9Q | SEC ↗ |
| 8 | Remedium Capital Partners, LLC | 3,363,558 | $$249M | +1,907,327 | +131.0% | 2Q | SEC ↗ |
| 9 | JANUS HENDERSON GROUP PLC | 3,312,328 | $$245M | +1,483,319 | +81.1% | 9Q | SEC ↗ |
| 10 | PERCEPTIVE ADVISORS LLC | 3,069,225 | $$227M | +1,839,780 | +149.6% | 10Q | SEC ↗ |
| 11 | Driehaus Capital Management LLC | 2,790,785 | $$207M | -91,635 | -3.2% | 11Q | SEC ↗ |
| 12 | STATE STREET CORP | 2,607,031 | $$193M | +344,192 | +15.2% | 9Q | SEC ↗ |
| 13 | Paradigm Biocapital Advisors LP | 1,957,266 | $$145M | +490,000 | +33.4% | 7Q | SEC ↗ |
| 14 | Commodore Capital LP | 1,912,380 | $$142M | -475,865 | -19.9% | 11Q | SEC ↗ |
| 15 | TCG Crossover Management, LLC | 1,900,582 | $$141M | — | +0.0% | 3Q | SEC ↗ |
| 16 | TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $$140M | — | +0.0% | 5Q | SEC ↗ |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | $$135M | +275,527 | +17.8% | 11Q | SEC ↗ |
| 18 | Capital International Investors | 1,746,129 | $$129M | -1,746,412 | -50.0% | 5Q | SEC ↗ |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | $$127M | +61,772 | +3.7% | 11Q | SEC ↗ |
| 20 | BRAIDWELL LP | 1,634,615 | $$121M | -943,789 | -36.6% | 9Q | SEC ↗ |
| 21 | RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | $$120M | — | +0.0% | 2Q | SEC ↗ |
| 22 | PRICE T ROWE ASSOCIATES INC /MD | 1,598,730 | $$118M | -3,152 | -0.2% | 9Q | SEC ↗ |
| 23 | Affinity Asset Advisors, LLC | 1,279,134 | $$95M | -153,457 | -10.7% | 11Q | SEC ↗ |
| 24 | BANK OF AMERICA CORP /DE | 1,228,093 | $$91M | +808,366 | +192.6% | 9Q | SEC ↗ |
| 25 | BAKER BROS. ADVISORS LP | 1,000,000 | $$74M | — | +0.0% | 3Q | SEC ↗ |
| 26 | JPMORGAN CHASE & CO | 979,299 | $$73M | +916,348 | +1455.7% | 11Q | SEC ↗ |
| 27 | FRANKLIN RESOURCES INC | 882,833 | $$65M | -226,441 | -20.4% | 10Q | SEC ↗ |
| 28 | Caligan Partners LP NEW | 878,127 | $$65M | — | +0.0% | 1Q | SEC ↗ |
| 29 | Siren, L.L.C. | 818,598 | $$61M | — | +0.0% | 6Q | SEC ↗ |
| 30 | Polar Capital Holdings Plc | 792,847 | $$59M | +52,521 | +7.1% | 11Q | SEC ↗ |
| 31 | DEERFIELD MANAGEMENT COMPANY, L.P. | 710,626 | $$53M | +96,961 | +15.8% | 5Q | SEC ↗ |
| 32 | UBS Group AG | 671,235 | $$50M | -9,331 | -1.4% | 10Q | SEC ↗ |
| 33 | Capital World Investors | 666,564 | $$49M | +466,392 | +233.0% | 6Q | SEC ↗ |
| 34 | EMERALD ADVISERS, LLC | 613,365 | $$45M | -22,744 | -3.6% | 7Q | SEC ↗ |
| 35 | Candriam S.C.A. | 610,282 | $$45M | -240,786 | -28.3% | 9Q | SEC ↗ |
| 36 | VANGUARD PORTFOLIO MANAGEMENT LLC NEW | 585,130 | $$43M | — | +0.0% | 1Q | SEC ↗ |
| 37 | NORTHERN TRUST CORP | 578,907 | $$43M | +17,884 | +3.2% | 9Q | SEC ↗ |
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT I | 562,653 | $$42M | -11,969 | -2.1% | 9Q | SEC ↗ |
| 39 | Blackstone Inc. | 500,998 | $$37M | — | +0.0% | 9Q | SEC ↗ |
| 40 | Pictet Asset Management Holding SA | 491,649 | $$36M | -422,311 | -46.2% | 8Q | SEC ↗ |
| 41 | VANGUARD FIDUCIARY TRUST CO NEW | 464,651 | $$34M | — | +0.0% | 1Q | SEC ↗ |
| 42 | EMERALD MUTUAL FUND ADVISERS TRUST | 408,113 | $$30M | -4,258 | -1.0% | 7Q | SEC ↗ |
| 43 | SAMLYN CAPITAL, LLC NEW | 396,661 | $$29M | — | +0.0% | 1Q | SEC ↗ |
| 44 | ADAR1 Capital Management, LLC | 338,323 | $$25M | +270,221 | +396.8% | 5Q | SEC ↗ |
| 45 | STEMPOINT CAPITAL LP | 335,212 | $$25M | +302,835 | +935.3% | 2Q | SEC ↗ |
| 46 | VICTORY CAPITAL MANAGEMENT INC | 292,126 | $$22M | +146,047 | +100.0% | 6Q | SEC ↗ |
| 47 | GOLDMAN SACHS GROUP INC | 269,938 | $$20M | -280,192 | -50.9% | 9Q | SEC ↗ |
| 48 | Woodline Partners LP | 265,892 | $$20M | — | +0.0% | 9Q | SEC ↗ |
| 49 | UBS AM, a distinct business unit of UB | 207,314 | $$15M | +145,098 | +233.2% | 8Q | SEC ↗ |
| 50 | BOOTHBAY FUND MANAGEMENT, LLC NEW | 193,031 | $$14M | — | +0.0% | 1Q | SEC ↗ |
Recent Activity
New Positions (20)
| Holder | Shares | Value |
|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | 6,114,802 | $$453M |
| Caligan Partners LP | 878,127 | $$65M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 585,130 | $$43M |
| VANGUARD FIDUCIARY TRUST CO | 464,651 | $$34M |
| SAMLYN CAPITAL, LLC | 396,661 | $$29M |
| BOOTHBAY FUND MANAGEMENT, LLC | 193,031 | $$14M |
| FIRST TRUST ADVISORS LP | 178,389 | $$13M |
| Ensign Peak Advisors, Inc | 148,537 | $$11M |
| CITADEL ADVISORS LLC | 63,904 | $$5M |
| PRUDENTIAL FINANCIAL INC | 59,555 | $$4M |
| Cinctive Capital Management LP | 35,935 | $$3M |
| VANGUARD ASSET MANAGEMENT, Ltd | 33,232 | $$2M |
| Vanguard Global Advisers, LLC | 31,141 | $$2M |
| XTX Topco Ltd | 24,435 | $$2M |
| Ellsworth Advisors, LLC | 21,963 | $$2M |
| RAYMOND JAMES FINANCIAL INC | 19,755 | $$1M |
| Seven Fleet Capital Management LP | 19,690 | $$1M |
| KENNEDY CAPITAL MANAGEMENT LLC | 16,873 | $$1M |
| Creative Planning | 15,486 | $$1M |
| Vanguard Investments Australia, Ltd | 12,813 | $$949K |
Sold Out (20)
| Holder | Prev Shares | Prev Value |
|---|---|---|
| Jefferies Financial Group Inc. | 1,388,854 | $$103M |
| Point72 Asset Management, L.P. | 662,351 | $$49M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 610,200 | $$45M |
| VOLORIDGE INVESTMENT MANAGEMENT, LL | 264,317 | $$20M |
| Deep Track Capital, LP | 219,015 | $$16M |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | 183,000 | $$14M |
| Parkman Healthcare Partners LLC | 124,485 | $$9M |
| JANE STREET GROUP, LLC | 96,057 | $$7M |
| Schonfeld Strategic Advisors LLC | 81,474 | $$6M |
| Foresite Capital Management VI LLC | 70,000 | $$5M |
| Opaleye Management Inc. | 65,000 | $$5M |
| DLD Asset Management, LP | 60,000 | $$4M |
| Verition Fund Management LLC | 48,496 | $$4M |
| RENAISSANCE TECHNOLOGIES LLC | 30,936 | $$2M |
| Jump Financial, LLC | 27,100 | $$2M |
| Optimize Financial Inc | 25,331 | $$2M |
| Squarepoint Ops LLC | 20,232 | $$1M |
| NATIXIS | 20,040 | $$1M |
| Quadrature Capital Ltd | 19,366 | $$1M |
| DARK FOREST CAPITAL MANAGEMENT LP | 14,733 | $$1M |
Biggest Increases (20)
| Holder | Added | Change % | Total Shares |
|---|---|---|---|
| Remedium Capital Partners, LLC | +1,907,327 | +131.0% | 3,363,558 |
| PERCEPTIVE ADVISORS LLC | +1,839,780 | +149.6% | 3,069,225 |
| JANUS HENDERSON GROUP PLC | +1,483,319 | +81.1% | 3,312,328 |
| VR ADVISER, LLC | +1,000,000 | +37.2% | 3,685,448 |
| VANGUARD GROUP INC | +984,344 | +32.3% | 4,035,074 |
| JPMORGAN CHASE & CO | +916,348 | +1455.7% | 979,299 |
| BANK OF AMERICA CORP /DE | +808,366 | +192.6% | 1,228,093 |
| Paradigm Biocapital Advisors LP | +490,000 | +33.4% | 1,957,266 |
| Capital World Investors | +466,392 | +233.0% | 666,564 |
| STATE STREET CORP | +344,192 | +15.2% | 2,607,031 |
| STEMPOINT CAPITAL LP | +302,835 | +935.3% | 335,212 |
| WELLINGTON MANAGEMENT GROUP LLP | +275,527 | +17.8% | 1,824,811 |
| ADAR1 Capital Management, LLC | +270,221 | +396.8% | 338,323 |
| VICTORY CAPITAL MANAGEMENT INC | +146,047 | +100.0% | 292,126 |
| UBS AM, a distinct business unit of | +145,098 | +233.2% | 207,314 |
| FMR LLC | +142,205 | +1.2% | 11,781,024 |
| AMERIPRISE FINANCIAL INC | +120,961 | +316.2% | 159,217 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | +96,961 | +15.8% | 710,626 |
| CITIGROUP INC | +67,162 | +204.2% | 100,058 |
| Rockefeller Capital Management L.P. | +62,904 | +5729.0% | 64,002 |
Biggest Decreases (20)
| Holder | Reduced | Change % | Total Shares |
|---|---|---|---|
| Capital International Investors | -1,746,412 | -50.0% | 1,746,129 |
| BRAIDWELL LP | -943,789 | -36.6% | 1,634,615 |
| Commodore Capital LP | -475,865 | -19.9% | 1,912,380 |
| Pictet Asset Management Holding SA | -422,311 | -46.2% | 491,649 |
| MILLENNIUM MANAGEMENT LLC | -332,005 | -81.3% | 76,194 |
| GOLDMAN SACHS GROUP INC | -280,192 | -50.9% | 269,938 |
| Candriam S.C.A. | -240,786 | -28.3% | 610,282 |
| FRANKLIN RESOURCES INC | -226,441 | -20.4% | 882,833 |
| Affinity Asset Advisors, LLC | -153,457 | -10.7% | 1,279,134 |
| MORGAN STANLEY | -151,988 | -45.4% | 182,734 |
| Patient Square Capital LP | -149,000 | -99.3% | 1,000 |
| BARCLAYS PLC | -136,738 | -74.9% | 45,786 |
| Driehaus Capital Management LLC | -91,635 | -3.2% | 2,790,785 |
| ARMISTICE CAPITAL, LLC | -75,495 | -38.4% | 120,931 |
| AlphaQuest LLC | -62,625 | -94.7% | 3,538 |
| HighVista Strategies LLC | -41,942 | -22.3% | 146,264 |
| DIMENSIONAL FUND ADVISORS LP | -29,593 | -38.3% | 47,697 |
| EMERALD ADVISERS, LLC | -22,744 | -3.6% | 613,365 |
| Invesco Ltd. | -18,544 | -12.3% | 132,390 |
| Balyasny Asset Management L.P. | -17,988 | -24.5% | 55,477 |