SYRE Institutional Ownership
Spyre Therapeutics, Inc.
1W: +8.8%
1M: +7.0%
3M: +5.0%
YTD: +204.7%
1Y: +466.2%
3Y: +711.0%
5Y: -51.4%
$93.19
+3.26 (+3.63%)
Weekly Expected Move ±5.3%
$83
$88
$93
$98
$103
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Institutional Ownership — SYRE
289
Institutional Holders
+81 vs prior quarter
0.0%
Ownership
+0.00pp
$8B
Total Invested
94
New Positions
104
Increased
77
Reduced
21
Closed
1.00
Put/Call Ratio
Ownership Trends
Top Institutional Holders (298 total)
| # | Holder | Shares | Value | Change | Change % | Holding Period | Filing |
|---|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,026,187 | $1.2B | +1,245,163 | +10.6% | 11Q | SEC ↗ |
| 2 | BlackRock, Inc. | 6,506,605 | $606M | +985,384 | +17.8% | 8Q | SEC ↗ |
| 3 | PERCEPTIVE ADVISORS LLC | 4,319,496 | $403M | +536,271 | +14.2% | 12Q | SEC ↗ |
| 4 | RTW INVESTMENTS, LP | 4,251,996 | $396M | +80,000 | +1.9% | 11Q | SEC ↗ |
| 5 | Paradigm Biocapital Advisors LP | 3,840,778 | $358M | +1,883,512 | +96.2% | 8Q | SEC ↗ |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 3,448,681 | $321M | +391,280 | +12.8% | 2Q | SEC ↗ |
| 7 | STATE STREET CORP | 3,057,416 | $285M | +450,385 | +17.3% | 10Q | SEC ↗ |
| 8 | Venrock Adviser, LLC | 2,985,448 | $278M | -700,000 | -19.0% | 11Q | SEC ↗ |
| 9 | PRICE T ROWE ASSOCIATES INC /MD | 2,960,855 | $276M | +1,362,125 | +85.2% | 10Q | SEC ↗ |
| 10 | Driehaus Capital Management LLC | 2,799,166 | $261M | +8,381 | +0.3% | 12Q | SEC ↗ |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 2,562,265 | $239M | +841,353 | +48.9% | 12Q | SEC ↗ |
| 12 | VANGUARD PORTFOLIO MANAGEMENT LLC | 2,330,098 | $217M | +1,744,968 | +298.2% | 2Q | SEC ↗ |
| 13 | Capital World Investors | 2,315,553 | $216M | +1,648,989 | +247.4% | 7Q | SEC ↗ |
| 14 | Jupiter Topco LLC NEW | 2,206,936 | $206M | — | +0.0% | 1Q | SEC ↗ |
| 15 | TCG Crossover Management, LLC | 1,900,582 | $177M | — | +0.0% | 4Q | SEC ↗ |
| 16 | TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $176M | — | +0.0% | 6Q | SEC ↗ |
| 17 | BANK OF AMERICA CORP /DE | 1,777,854 | $166M | +549,761 | +44.8% | 10Q | SEC ↗ |
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. NEW | 1,722,300 | $161M | — | +0.0% | 1Q | SEC ↗ |
| 19 | JANUS HENDERSON GROUP PLC | 1,656,164 | $154M | -172,845 | -9.5% | 9Q | SEC ↗ |
| 20 | WELLINGTON MANAGEMENT GROUP LLP | 1,581,505 | $147M | -243,306 | -13.3% | 12Q | SEC ↗ |
| 21 | GOLDMAN SACHS GROUP INC | 1,478,059 | $138M | +1,208,121 | +447.6% | 10Q | SEC ↗ |
| 22 | FRANKLIN RESOURCES INC | 1,472,943 | $137M | +590,110 | +66.8% | 11Q | SEC ↗ |
| 23 | Remedium Capital Partners, LLC | 1,464,169 | $136M | +7,938 | +0.5% | 3Q | SEC ↗ |
| 24 | Affinity Asset Advisors, LLC | 1,279,134 | $119M | — | +0.0% | 12Q | SEC ↗ |
| 25 | JPMORGAN CHASE & CO | 1,093,026 | $102M | +113,727 | +11.6% | 12Q | SEC ↗ |
| 26 | Holocene Advisors, LP NEW | 1,015,170 | $95M | — | +0.0% | 1Q | SEC ↗ |
| 27 | MARSHALL WACE, LLP | 991,693 | $92M | +852,434 | +612.1% | 2Q | SEC ↗ |
| 28 | Polar Capital Holdings Plc | 988,009 | $92M | +195,162 | +24.6% | 12Q | SEC ↗ |
| 29 | Siren, L.L.C. | 968,598 | $90M | +150,000 | +18.3% | 7Q | SEC ↗ |
| 30 | Capital International Investors | 955,196 | $89M | -790,933 | -45.3% | 6Q | SEC ↗ |
| 31 | BRAIDWELL LP | 879,467 | $82M | -53,356 | -5.7% | 11Q | SEC ↗ |
| 32 | Commodore Capital LP | 846,786 | $79M | -1,065,594 | -55.7% | 12Q | SEC ↗ |
| 33 | UBS Group AG | 843,071 | $79M | +171,836 | +25.6% | 11Q | SEC ↗ |
| 34 | NORTHERN TRUST CORP | 674,529 | $63M | +95,622 | +16.5% | 10Q | SEC ↗ |
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT I | 652,958 | $61M | +90,305 | +16.0% | 10Q | SEC ↗ |
| 36 | Sixth Street Partners Management Compa NEW | 652,958 | $61M | — | +0.0% | 1Q | SEC ↗ |
| 37 | Pictet Asset Management Holding SA | 628,138 | $59M | +136,489 | +27.8% | 9Q | SEC ↗ |
| 38 | EMERALD ADVISERS, LLC | 567,430 | $53M | -45,935 | -7.5% | 8Q | SEC ↗ |
| 39 | VICTORY CAPITAL MANAGEMENT INC | 553,980 | $52M | +261,854 | +89.6% | 7Q | SEC ↗ |
| 40 | VANGUARD FIDUCIARY TRUST CO | 551,389 | $51M | +86,738 | +18.7% | 2Q | SEC ↗ |
| 41 | Candriam S.C.A. | 546,312 | $51M | -63,970 | -10.5% | 10Q | SEC ↗ |
| 42 | UBS AM, a distinct business unit of UB | 522,071 | $49M | +314,757 | +151.8% | 9Q | SEC ↗ |
| 43 | MORGAN STANLEY | 499,963 | $47M | +253,244 | +102.6% | 12Q | SEC ↗ |
| 44 | VOYA INVESTMENT MANAGEMENT LLC | 431,694 | $40M | +377,724 | +699.9% | 3Q | SEC ↗ |
| 45 | EMERALD MUTUAL FUND ADVISERS TRUST | 401,271 | $37M | -6,842 | -1.7% | 8Q | SEC ↗ |
| 46 | SAMLYN CAPITAL, LLC | 400,075 | $37M | +3,414 | +0.9% | 2Q | SEC ↗ |
| 47 | AMERIPRISE FINANCIAL INC | 356,082 | $33M | +196,865 | +123.6% | 3Q | SEC ↗ |
| 48 | Integral Health Asset Management, LLC NEW | 325,000 | $30M | — | +0.0% | 1Q | SEC ↗ |
| 49 | Woodline Partners LP | 306,049 | $29M | +40,157 | +15.1% | 10Q | SEC ↗ |
| 50 | JENNISON ASSOCIATES LLC NEW | 303,180 | $28M | — | +0.0% | 1Q | SEC ↗ |
Recent Activity
New Positions (20)
| Holder | Shares | Value |
|---|---|---|
| Jupiter Topco LLC | 2,206,936 | $206M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,722,300 | $161M |
| Holocene Advisors, LP | 1,015,170 | $95M |
| Sixth Street Partners Management Co | 652,958 | $61M |
| Integral Health Asset Management, L | 325,000 | $30M |
| JENNISON ASSOCIATES LLC | 303,180 | $28M |
| Bellevue Group AG | 229,931 | $21M |
| Cormorant Asset Management, LP | 225,000 | $21M |
| EVENTIDE ASSET MANAGEMENT, LLC | 201,616 | $19M |
| ORBIMED ADVISORS LLC | 186,145 | $17M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 182,931 | $17M |
| NEUBERGER BERMAN GROUP LLC | 180,884 | $17M |
| Soleus Capital Management, L.P. | 147,000 | $14M |
| Squarepoint Ops LLC | 139,605 | $13M |
| Rhenman & Partners Asset Management | 119,300 | $11M |
| Boxer Capital Management, LLC | 100,000 | $9M |
| FEDERATED HERMES, INC. | 85,950 | $8M |
| Granahan Investment Management, LLC | 82,991 | $8M |
| Trexquant Investment LP | 67,007 | $6M |
| Informed Momentum Co LLC | 60,393 | $6M |
Sold Out (20)
| Holder | Prev Shares | Prev Value |
|---|---|---|
| Fairmount Funds Management LLC | 4,018,101 | $374M |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | $151M |
| BAKER BROS. ADVISORS LP | 1,000,000 | $93M |
| Caligan Partners LP | 878,127 | $82M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 710,626 | $66M |
| Point72 Asset Management, L.P. | 662,351 | $62M |
| Parkman Healthcare Partners LLC | 124,485 | $12M |
| ExodusPoint Capital Management, LP | 87,065 | $8M |
| ALPS ADVISORS INC | 63,939 | $6M |
| Optimize Financial Inc | 25,331 | $2M |
| Assenagon Asset Management S.A. | 18,647 | $2M |
| Carlyle Group Inc. | 9,620 | $896K |
| CAXTON CORP | 8,919 | $831K |
| RWC Asset Management LLP | 8,166 | $761K |
| CAPSTONE INVESTMENT ADVISORS, LLC | 7,537 | $702K |
| Scientech Research LLC | 7,088 | $661K |
| Arrowpoint Investment Partners (Sin | 6,140 | $572K |
| DeepCurrents Investment Group LLC | 4,740 | $442K |
| AMALGAMATED BANK | 2,165 | $202K |
| Patient Square Capital LP | 1,000 | $93K |
Biggest Increases (20)
| Holder | Added | Change % | Total Shares |
|---|---|---|---|
| Paradigm Biocapital Advisors LP | +1,883,512 | +96.2% | 3,840,778 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +1,744,968 | +298.2% | 2,330,098 |
| Capital World Investors | +1,648,989 | +247.4% | 2,315,553 |
| PRICE T ROWE ASSOCIATES INC /MD | +1,362,125 | +85.2% | 2,960,855 |
| FMR LLC | +1,245,163 | +10.6% | 13,026,187 |
| GOLDMAN SACHS GROUP INC | +1,208,121 | +447.6% | 1,478,059 |
| BlackRock, Inc. | +985,384 | +17.8% | 6,506,605 |
| MARSHALL WACE, LLP | +852,434 | +612.1% | 991,693 |
| GEODE CAPITAL MANAGEMENT, LLC | +841,353 | +48.9% | 2,562,265 |
| FRANKLIN RESOURCES INC | +590,110 | +66.8% | 1,472,943 |
| BANK OF AMERICA CORP /DE | +549,761 | +44.8% | 1,777,854 |
| PERCEPTIVE ADVISORS LLC | +536,271 | +14.2% | 4,319,496 |
| STATE STREET CORP | +450,385 | +17.3% | 3,057,416 |
| VANGUARD CAPITAL MANAGEMENT LLC | +391,280 | +12.8% | 3,448,681 |
| VOYA INVESTMENT MANAGEMENT LLC | +377,724 | +699.9% | 431,694 |
| UBS AM, a distinct business unit of | +314,757 | +151.8% | 522,071 |
| VICTORY CAPITAL MANAGEMENT INC | +261,854 | +89.6% | 553,980 |
| MORGAN STANLEY | +253,244 | +102.6% | 499,963 |
| BNP PARIBAS FINANCIAL MARKETS | +241,293 | +1295.2% | 259,923 |
| AMERIPRISE FINANCIAL INC | +196,865 | +123.6% | 356,082 |
Biggest Decreases (20)
| Holder | Reduced | Change % | Total Shares |
|---|---|---|---|
| Commodore Capital LP | -1,065,594 | -55.7% | 846,786 |
| Capital International Investors | -790,933 | -45.3% | 955,196 |
| Venrock Adviser, LLC | -700,000 | -19.0% | 2,985,448 |
| WELLINGTON MANAGEMENT GROUP LLP | -243,306 | -13.3% | 1,581,505 |
| BOOTHBAY FUND MANAGEMENT, LLC | -186,578 | -96.7% | 6,453 |
| JANUS HENDERSON GROUP PLC | -172,845 | -9.5% | 1,656,164 |
| Blackstone Inc. | -172,670 | -59.0% | 120,177 |
| FIRST TRUST ADVISORS LP | -168,610 | -94.5% | 9,779 |
| SILVERARC CAPITAL MANAGEMENT, LLC | -126,659 | -67.9% | 59,959 |
| HighVista Strategies LLC | -68,457 | -46.8% | 77,807 |
| Candriam S.C.A. | -63,970 | -10.5% | 546,312 |
| STEMPOINT CAPITAL LP | -60,680 | -36.2% | 106,926 |
| ADAR1 Capital Management, LLC | -54,341 | -16.1% | 283,982 |
| BRAIDWELL LP | -53,356 | -5.7% | 879,467 |
| EMERALD ADVISERS, LLC | -45,935 | -7.5% | 567,430 |
| FRED ALGER MANAGEMENT, LLC | -30,619 | -51.5% | 28,834 |
| B Group, Inc. | -30,000 | -30.0% | 70,000 |
| Ensign Peak Advisors, Inc | -21,917 | -14.8% | 126,620 |
| TD Asset Management Inc | -21,400 | -15.6% | 115,990 |
| Rafferty Asset Management, LLC | -20,153 | -35.4% | 36,767 |