UPB Institutional Ownership
Upstream Bio, Inc.
1W: -6.0%
1M: -22.2%
3M: -31.9%
YTD: -80.7%
1Y: -70.9%
$5.04
+0.00 (+0.00%)
Weekly Expected Move ±6.0%
$4
$5
$5
$5
$6
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Institutional Ownership — UPB
178
Institutional Holders
+0 vs prior quarter
0.0%
Ownership
+0.00pp
$350M
Total Invested
39
New Positions
64
Increased
55
Reduced
27
Closed
0.75
Put/Call Ratio
Ownership Trends
Top Institutional Holders (206 total)
| # | Holder | Shares | Value | Change | Change % | Holding Period | Filing |
|---|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,162,897 | $41M | +61,334 | +0.8% | 7Q | SEC ↗ |
| 2 | ORBIMED ADVISORS LLC | 5,693,589 | $29M | — | +0.0% | 7Q | SEC ↗ |
| 3 | NORGES BANK NEW | 3,768,619 | $19M | — | +0.0% | 1Q | SEC ↗ |
| 4 | BlackRock, Inc. | 3,753,358 | $19M | +382,669 | +11.4% | 7Q | SEC ↗ |
| 5 | Decheng Capital LLC | 2,724,868 | $14M | — | +0.0% | 7Q | SEC ↗ |
| 6 | ENAVATE SCIENCES GP, LLC | 2,459,703 | $12M | — | +0.0% | 7Q | SEC ↗ |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 1,876,734 | $9M | +3,160 | +0.2% | 2Q | SEC ↗ |
| 8 | MILLENNIUM MANAGEMENT LLC | 1,143,775 | $6M | +206,452 | +22.0% | 4Q | SEC ↗ |
| 9 | D. E. Shaw & Co., Inc. | 1,036,044 | $5M | +215,564 | +26.3% | 3Q | SEC ↗ |
| 10 | JPMORGAN CHASE & CO | 1,012,044 | $5M | +549,043 | +118.6% | 7Q | SEC ↗ |
| 11 | Qube Research & Technologies Ltd | 978,500 | $5M | +359,179 | +58.0% | 2Q | SEC ↗ |
| 12 | Parkman Healthcare Partners LLC | 935,247 | $5M | +148,464 | +18.9% | 6Q | SEC ↗ |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 931,261 | $5M | -19,356 | -2.0% | 7Q | SEC ↗ |
| 14 | SEB Asset Management AB | 878,473 | $4M | — | +0.0% | 2Q | SEC ↗ |
| 15 | Woodline Partners LP | 831,481 | $4M | — | +0.0% | 7Q | SEC ↗ |
| 16 | STATE STREET CORP | 766,323 | $4M | +60,973 | +8.6% | 7Q | SEC ↗ |
| 17 | VANGUARD PORTFOLIO MANAGEMENT LLC | 712,667 | $4M | -15,044 | -2.1% | 2Q | SEC ↗ |
| 18 | Y-Intercept (Hong Kong) Ltd | 693,555 | $3M | -307,076 | -30.7% | 3Q | SEC ↗ |
| 19 | Bain Capital Life Sciences Investors, | 600,949 | $3M | -266,262 | -30.7% | 7Q | SEC ↗ |
| 20 | AQR CAPITAL MANAGEMENT LLC | 544,869 | $3M | +472,698 | +655.0% | 6Q | SEC ↗ |
| 21 | MORGAN STANLEY | 524,632 | $3M | -27,977 | -5.1% | 7Q | SEC ↗ |
| 22 | BNP PARIBAS FINANCIAL MARKETS | 511,546 | $3M | +385,546 | +306.0% | 7Q | SEC ↗ |
| 23 | Walleye Capital LLC NEW | 498,490 | $3M | — | +0.0% | 1Q | SEC ↗ |
| 24 | Trexquant Investment LP | 466,430 | $2M | +289,773 | +164.0% | 3Q | SEC ↗ |
| 25 | Point72 Asset Management, L.P. | 453,011 | $2M | +274,843 | +154.3% | 2Q | SEC ↗ |
| 26 | BANK OF AMERICA CORP /DE | 391,762 | $2M | +343,302 | +708.4% | 7Q | SEC ↗ |
| 27 | DIMENSIONAL FUND ADVISORS LP | 381,613 | $2M | +301,611 | +377.0% | 2Q | SEC ↗ |
| 28 | Altshuler Shaham Ltd | 380,061 | $2M | — | +0.0% | 6Q | SEC ↗ |
| 29 | ARROWSTREET CAPITAL, LIMITED PARTNERSH | 357,756 | $2M | +172,669 | +93.3% | 2Q | SEC ↗ |
| 30 | SAMSARA BIOCAPITAL, LLC | 353,717 | $2M | -382,330 | -51.9% | 7Q | SEC ↗ |
| 31 | Propel Bio Management, LLC | 350,389 | $2M | +8,610 | +2.5% | 2Q | SEC ↗ |
| 32 | WELLINGTON MANAGEMENT GROUP LLP | 342,353 | $2M | — | +0.0% | 7Q | SEC ↗ |
| 33 | NORTHERN TRUST CORP | 297,346 | $1M | +36,354 | +13.9% | 7Q | SEC ↗ |
| 34 | Squarepoint Ops LLC | 290,904 | $1M | +246,278 | +551.9% | 2Q | SEC ↗ |
| 35 | Voleon Capital Management LP NEW | 285,234 | $1M | — | +0.0% | 1Q | SEC ↗ |
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT I | 262,456 | $1M | +4,727 | +1.8% | 7Q | SEC ↗ |
| 37 | Sixth Street Partners Management Compa NEW | 262,456 | $1M | — | +0.0% | 1Q | SEC ↗ |
| 38 | JACOBS LEVY EQUITY MANAGEMENT, INC NEW | 253,092 | $1M | — | +0.0% | 1Q | SEC ↗ |
| 39 | GOLDMAN SACHS GROUP INC | 246,917 | $1M | -69,670 | -22.0% | 4Q | SEC ↗ |
| 40 | XTX Topco Ltd | 242,346 | $1M | +33,069 | +15.8% | 3Q | SEC ↗ |
| 41 | DEUTSCHE BANK AG | 241,447 | $1M | +60,558 | +33.5% | 7Q | SEC ↗ |
| 42 | VANGUARD FIDUCIARY TRUST CO | 239,616 | $1M | +15,459 | +6.9% | 2Q | SEC ↗ |
| 43 | UBS Group AG | 234,714 | $1M | +3,460 | +1.5% | 7Q | SEC ↗ |
| 44 | Schonfeld Strategic Advisors LLC | 225,760 | $1M | +64,411 | +39.9% | 6Q | SEC ↗ |
| 45 | Jump Financial, LLC | 223,223 | $1M | -96,177 | -30.1% | 2Q | SEC ↗ |
| 46 | SPHERA FUNDS MANAGEMENT LTD. | 219,700 | $1M | -138,300 | -38.6% | 2Q | SEC ↗ |
| 47 | ACADIAN ASSET MANAGEMENT LLC NEW | 175,110 | $883K | — | +0.0% | 1Q | SEC ↗ |
| 48 | HRT FINANCIAL LP NEW | 170,590 | $860K | — | +0.0% | 1Q | SEC ↗ |
| 49 | Boxer Capital Management, LLC | 150,000 | $756K | — | +0.0% | 3Q | SEC ↗ |
| 50 | RENAISSANCE TECHNOLOGIES LLC | 131,300 | $662K | +69,200 | +111.4% | 3Q | SEC ↗ |
Recent Activity
New Positions (20)
| Holder | Shares | Value |
|---|---|---|
| NORGES BANK | 3,768,619 | $19M |
| Walleye Capital LLC | 498,490 | $3M |
| Voleon Capital Management LP | 285,234 | $1M |
| Sixth Street Partners Management Co | 262,456 | $1M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 253,092 | $1M |
| ACADIAN ASSET MANAGEMENT LLC | 175,110 | $883K |
| HRT FINANCIAL LP | 170,590 | $860K |
| ALGERT GLOBAL LLC | 118,630 | $598K |
| Brevan Howard Capital Management LP | 50,369 | $254K |
| Allspring Global Investments Holdin | 43,182 | $218K |
| TWO SIGMA INVESTMENTS, LP | 42,325 | $213K |
| nVerses Capital, LLC | 24,029 | $121K |
| Graham Capital Management, L.P. | 22,508 | $113K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 22,385 | $113K |
| Verdad Advisers, LP | 21,810 | $110K |
| SG Americas Securities, LLC | 20,338 | $103K |
| SEI INVESTMENTS CO | 20,026 | $101K |
| WINTON GROUP Ltd | 19,800 | $100K |
| IEQ CAPITAL, LLC | 19,535 | $98K |
| Quadrature Capital Ltd | 17,988 | $91K |
Sold Out (20)
| Holder | Prev Shares | Prev Value |
|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,527,958 | $8M |
| Omega Fund Management, LLC | 1,326,293 | $7M |
| VR ADVISER, LLC | 1,169,298 | $6M |
| FEDERATED HERMES, INC. | 979,758 | $5M |
| Integral Health Asset Management, L | 750,000 | $4M |
| Pictet Asset Management Holding SA | 733,431 | $4M |
| Vestal Point Capital, LP | 720,000 | $4M |
| Siren, L.L.C. | 588,450 | $3M |
| Nantahala Capital Management, LLC | 400,000 | $2M |
| GREAT POINT PARTNERS LLC | 300,000 | $2M |
| Alyeska Investment Group, L.P. | 298,329 | $2M |
| JENNISON ASSOCIATES LLC | 288,847 | $1M |
| Prosight Management, LP | 241,123 | $1M |
| Squadron Capital Management LLC | 230,650 | $1M |
| TCG Crossover Management, LLC | 181,063 | $913K |
| SummitTX Capital, L.P. | 116,724 | $588K |
| Artia Global Partners LP | 68,653 | $346K |
| MARSHALL WACE, LLP | 66,770 | $337K |
| Exome Asset Management LLC | 64,845 | $327K |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $252K |
Biggest Increases (20)
| Holder | Added | Change % | Total Shares |
|---|---|---|---|
| JPMORGAN CHASE & CO | +549,043 | +118.6% | 1,012,044 |
| AQR CAPITAL MANAGEMENT LLC | +472,698 | +655.0% | 544,869 |
| BNP PARIBAS FINANCIAL MARKETS | +385,546 | +306.0% | 511,546 |
| BlackRock, Inc. | +382,669 | +11.4% | 3,753,358 |
| Qube Research & Technologies Ltd | +359,179 | +58.0% | 978,500 |
| BANK OF AMERICA CORP /DE | +343,302 | +708.4% | 391,762 |
| DIMENSIONAL FUND ADVISORS LP | +301,611 | +377.0% | 381,613 |
| Trexquant Investment LP | +289,773 | +164.0% | 466,430 |
| Point72 Asset Management, L.P. | +274,843 | +154.3% | 453,011 |
| Squarepoint Ops LLC | +246,278 | +551.9% | 290,904 |
| D. E. Shaw & Co., Inc. | +215,564 | +26.3% | 1,036,044 |
| MILLENNIUM MANAGEMENT LLC | +206,452 | +22.0% | 1,143,775 |
| ARROWSTREET CAPITAL, LIMITED PARTNE | +172,669 | +93.3% | 357,756 |
| Parkman Healthcare Partners LLC | +148,464 | +18.9% | 935,247 |
| RENAISSANCE TECHNOLOGIES LLC | +69,200 | +111.4% | 131,300 |
| Schonfeld Strategic Advisors LLC | +64,411 | +39.9% | 225,760 |
| FMR LLC | +61,334 | +0.8% | 8,162,897 |
| STATE STREET CORP | +60,973 | +8.6% | 766,323 |
| DEUTSCHE BANK AG | +60,558 | +33.5% | 241,447 |
| EntryPoint Capital, LLC | +55,878 | +76.0% | 129,446 |