UPB NASDAQ
Upstream Bio, Inc.
1W: -3.8%
1M: -12.2%
3M: +4.7%
YTD: -67.6%
1Y: +11.6%
$8.37
-0.09 (-1.06%)
After Hours: $8.96 (+0.59, +6.99%)
Weekly Expected Move ±7.0%
$8
$8
$9
$10
$10
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Income Statement
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Balance Sheet
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ETF Exposure
Dark Pool
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Institutional Ownership — UPB
177
Institutional Holders
+32 vs prior quarter
0.0%
Ownership
+0.00pp
$356M
Total Invested
42
New Positions
42
Increased
84
Reduced
53
Closed
1.50
Put/Call Ratio
Ownership Trends
Top Institutional Holders (184 total)
| # | Holder | Shares | Value | Change | Change % | Holding Period | Filing |
|---|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,101,563 | $$68M | +583,361 | +7.8% | 6Q | SEC ↗ |
| 2 | ORBIMED ADVISORS LLC | 5,693,589 | $$48M | — | +0.0% | 6Q | SEC ↗ |
| 3 | VANGUARD CAPITAL MANAGEMENT LLC NEW | 3,747,148 | $$31M | — | +0.0% | 1Q | SEC ↗ |
| 4 | BlackRock, Inc. | 3,370,689 | $$28M | +26,185 | +0.8% | 6Q | SEC ↗ |
| 5 | NORGES BANK NEW | 2,882,647 | $$24M | — | +0.0% | 1Q | SEC ↗ |
| 6 | Decheng Capital LLC | 2,724,868 | $$23M | -418,210 | -13.3% | 6Q | SEC ↗ |
| 7 | ENAVATE SCIENCES GP, LLC | 2,459,703 | $$21M | — | +0.0% | 6Q | SEC ↗ |
| 8 | VANGUARD GROUP INC | 2,388,439 | $$20M | -54,112 | -2.2% | 5Q | SEC ↗ |
| 9 | VR ADVISER, LLC | 1,169,298 | $$10M | — | +0.0% | 5Q | SEC ↗ |
| 10 | Y-Intercept (Hong Kong) Ltd | 1,000,631 | $$8M | +954,072 | +2049.2% | 2Q | SEC ↗ |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 950,617 | $$8M | +98,709 | +11.6% | 6Q | SEC ↗ |
| 12 | SEB Asset Management AB NEW | 878,473 | $$7M | — | +0.0% | 1Q | SEC ↗ |
| 13 | Bain Capital Life Sciences Investors, | 867,211 | $$7M | -462,333 | -34.8% | 6Q | SEC ↗ |
| 14 | Woodline Partners LP | 831,481 | $$7M | +71,229 | +9.4% | 6Q | SEC ↗ |
| 15 | Parkman Healthcare Partners LLC | 786,783 | $$7M | -47,776 | -5.7% | 5Q | SEC ↗ |
| 16 | SAMSARA BIOCAPITAL, LLC | 736,047 | $$6M | -226,107 | -23.5% | 5Q | SEC ↗ |
| 17 | Pictet Asset Management Holding SA | 733,431 | $$6M | -39,717 | -5.1% | 2Q | SEC ↗ |
| 18 | VANGUARD PORTFOLIO MANAGEMENT LLC NEW | 727,711 | $$6M | — | +0.0% | 1Q | SEC ↗ |
| 19 | Vestal Point Capital, LP NEW | 720,000 | $$6M | — | +0.0% | 1Q | SEC ↗ |
| 20 | STATE STREET CORP | 705,350 | $$6M | -613,876 | -46.5% | 6Q | SEC ↗ |
| 21 | HSBC HOLDINGS PLC NEW | 640,326 | $$5M | — | +0.0% | 1Q | SEC ↗ |
| 22 | Qube Research & Technologies Ltd NEW | 619,321 | $$5M | — | +0.0% | 1Q | SEC ↗ |
| 23 | MILLENNIUM MANAGEMENT LLC | 517,264 | $$4M | +477,151 | +1189.5% | 2Q | SEC ↗ |
| 24 | Nantahala Capital Management, LLC | 494,971 | $$4M | -100,000 | -16.8% | 5Q | SEC ↗ |
| 25 | JPMORGAN CHASE & CO | 463,001 | $$4M | +352,721 | +319.8% | 6Q | SEC ↗ |
| 26 | Altshuler Shaham Ltd | 380,061 | $$3M | -961,479 | -71.7% | 5Q | SEC ↗ |
| 27 | MARSHALL WACE, LLP | 343,791 | $$3M | -524,208 | -60.4% | 5Q | SEC ↗ |
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 342,353 | $$3M | -552,380 | -61.7% | 6Q | SEC ↗ |
| 29 | Propel Bio Management, LLC NEW | 341,779 | $$3M | — | +0.0% | 1Q | SEC ↗ |
| 30 | Jump Financial, LLC NEW | 319,400 | $$3M | — | +0.0% | 1Q | SEC ↗ |
| 31 | GOLDMAN SACHS GROUP INC | 316,587 | $$3M | -350,375 | -52.5% | 3Q | SEC ↗ |
| 32 | GREAT POINT PARTNERS LLC | 300,000 | $$3M | — | +0.0% | 5Q | SEC ↗ |
| 33 | Alyeska Investment Group, L.P. NEW | 298,329 | $$2M | — | +0.0% | 1Q | SEC ↗ |
| 34 | NORTHERN TRUST CORP | 260,992 | $$2M | +24,193 | +10.2% | 6Q | SEC ↗ |
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT I | 257,729 | $$2M | -27,202 | -9.5% | 6Q | SEC ↗ |
| 36 | Prosight Management, LP NEW | 241,123 | $$2M | — | +0.0% | 1Q | SEC ↗ |
| 37 | UBS Group AG | 231,254 | $$2M | -1,574,989 | -87.2% | 6Q | SEC ↗ |
| 38 | Squadron Capital Management LLC NEW | 230,650 | $$2M | — | +0.0% | 1Q | SEC ↗ |
| 39 | VANGUARD FIDUCIARY TRUST CO NEW | 224,157 | $$2M | — | +0.0% | 1Q | SEC ↗ |
| 40 | XTX Topco Ltd | 209,277 | $$2M | +194,186 | +1286.8% | 2Q | SEC ↗ |
| 41 | ARROWSTREET CAPITAL, LIMITED PARTNERSH NEW | 185,087 | $$2M | — | +0.0% | 1Q | SEC ↗ |
| 42 | TCG Crossover Management, LLC | 181,063 | $$2M | -562,823 | -75.7% | 6Q | SEC ↗ |
| 43 | DEUTSCHE BANK AG | 180,889 | $$2M | +53,074 | +41.5% | 6Q | SEC ↗ |
| 44 | Point72 Asset Management, L.P. NEW | 178,168 | $$1M | — | +0.0% | 1Q | SEC ↗ |
| 45 | Trexquant Investment LP | 176,657 | $$1M | +145,608 | +469.0% | 2Q | SEC ↗ |
| 46 | Schonfeld Strategic Advisors LLC | 161,349 | $$1M | +45,542 | +39.3% | 5Q | SEC ↗ |
| 47 | Boxer Capital Management, LLC | 150,000 | $$1M | — | +0.0% | 2Q | SEC ↗ |
| 48 | BNP PARIBAS FINANCIAL MARKETS | 126,000 | $$1M | +121,024 | +2432.2% | 6Q | SEC ↗ |
| 49 | MORGAN STANLEY | 122,068 | $$1M | +34,533 | +39.5% | 5Q | SEC ↗ |
| 50 | ExodusPoint Capital Management, LP | 91,431 | $$765K | +16,029 | +21.3% | 2Q | SEC ↗ |
Recent Activity
New Positions (20)
| Holder | Shares | Value |
|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | 3,747,148 | $$31M |
| NORGES BANK | 2,882,647 | $$24M |
| SEB Asset Management AB | 878,473 | $$7M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 727,711 | $$6M |
| Vestal Point Capital, LP | 720,000 | $$6M |
| HSBC HOLDINGS PLC | 640,326 | $$5M |
| Qube Research & Technologies Ltd | 619,321 | $$5M |
| Propel Bio Management, LLC | 341,779 | $$3M |
| Jump Financial, LLC | 319,400 | $$3M |
| Alyeska Investment Group, L.P. | 298,329 | $$2M |
| Prosight Management, LP | 241,123 | $$2M |
| Squadron Capital Management LLC | 230,650 | $$2M |
| VANGUARD FIDUCIARY TRUST CO | 224,157 | $$2M |
| ARROWSTREET CAPITAL, LIMITED PARTNE | 185,087 | $$2M |
| Point72 Asset Management, L.P. | 178,168 | $$1M |
| DIMENSIONAL FUND ADVISORS LP | 80,002 | $$670K |
| Simplify Asset Management Inc. | 77,793 | $$651K |
| EntryPoint Capital, LLC | 73,568 | $$616K |
| Squarepoint Ops LLC | 44,626 | $$374K |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,671 | $$349K |
Sold Out (20)
| Holder | Prev Shares | Prev Value |
|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,527,958 | $$13M |
| Omega Fund Management, LLC | 1,326,293 | $$11M |
| Integral Health Asset Management, L | 750,000 | $$6M |
| Siren, L.L.C. | 588,450 | $$5M |
| JENNISON ASSOCIATES LLC | 288,847 | $$2M |
| Ikarian Capital, LLC | 161,113 | $$1M |
| SummitTX Capital, L.P. | 116,724 | $$977K |
| BALYASNY ASSET MANAGEMENT L.P. | 73,131 | $$612K |
| Artia Global Partners LP | 68,653 | $$575K |
| Exome Asset Management LLC | 64,845 | $$543K |
| BOOTHBAY FUND MANAGEMENT, LLC | 61,299 | $$513K |
| AMERIPRISE FINANCIAL INC | 56,557 | $$473K |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $$418K |
| Rafferty Asset Management, LLC | 38,683 | $$324K |
| NOMURA HOLDINGS INC | 28,290 | $$237K |
| Caption Management, LLC | 18,196 | $$152K |
| PSP Research LLC | 17,634 | $$148K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,560 | $$139K |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,503 | $$130K |
| PROFUND ADVISORS LLC | 14,582 | $$122K |
Biggest Increases (20)
| Holder | Added | Change % | Total Shares |
|---|---|---|---|
| Y-Intercept (Hong Kong) Ltd | +954,072 | +2049.2% | 1,000,631 |
| FMR LLC | +583,361 | +7.8% | 8,101,563 |
| MILLENNIUM MANAGEMENT LLC | +477,151 | +1189.5% | 517,264 |
| JPMORGAN CHASE & CO | +352,721 | +319.8% | 463,001 |
| XTX Topco Ltd | +194,186 | +1286.8% | 209,277 |
| Trexquant Investment LP | +145,608 | +469.0% | 176,657 |
| BNP PARIBAS FINANCIAL MARKETS | +121,024 | +2432.2% | 126,000 |
| GEODE CAPITAL MANAGEMENT, LLC | +98,709 | +11.6% | 950,617 |
| Woodline Partners LP | +71,229 | +9.4% | 831,481 |
| DEUTSCHE BANK AG | +53,074 | +41.5% | 180,889 |
| RENAISSANCE TECHNOLOGIES LLC | +45,700 | +278.7% | 62,100 |
| Schonfeld Strategic Advisors LLC | +45,542 | +39.3% | 161,349 |
| AQR CAPITAL MANAGEMENT LLC | +41,668 | +136.6% | 72,171 |
| MORGAN STANLEY | +34,533 | +39.5% | 122,068 |
| Quantinno Capital Management LP | +33,974 | +220.4% | 49,389 |
| BlackRock, Inc. | +26,185 | +0.8% | 3,370,689 |
| CALIFORNIA STATE TEACHERS RETIREMEN | +25,009 | +170.7% | 39,661 |
| NORTHERN TRUST CORP | +24,193 | +10.2% | 260,992 |
| Swiss National Bank | +21,500 | +80.8% | 48,100 |
| NISA INVESTMENT ADVISORS, LLC | +19,158 | +4789.5% | 19,558 |
Biggest Decreases (20)
| Holder | Reduced | Change % | Total Shares |
|---|---|---|---|
| UBS Group AG | -1,574,989 | -87.2% | 231,254 |
| Altshuler Shaham Ltd | -961,479 | -71.7% | 380,061 |
| STATE STREET CORP | -613,876 | -46.5% | 705,350 |
| TCG Crossover Management, LLC | -562,823 | -75.7% | 181,063 |
| WELLINGTON MANAGEMENT GROUP LLP | -552,380 | -61.7% | 342,353 |
| MARSHALL WACE, LLP | -524,208 | -60.4% | 343,791 |
| BARCLAYS PLC | -499,779 | -95.3% | 24,720 |
| Bain Capital Life Sciences Investor | -462,333 | -34.8% | 867,211 |
| Decheng Capital LLC | -418,210 | -13.3% | 2,724,868 |
| GOLDMAN SACHS GROUP INC | -350,375 | -52.5% | 316,587 |
| SAMSARA BIOCAPITAL, LLC | -226,107 | -23.5% | 736,047 |
| Invesco Ltd. | -122,676 | -75.2% | 40,510 |
| Nantahala Capital Management, LLC | -100,000 | -16.8% | 494,971 |
| VANGUARD GROUP INC | -54,112 | -2.2% | 2,388,439 |
| Parkman Healthcare Partners LLC | -47,776 | -5.7% | 786,783 |
| SUSQUEHANNA INTERNATIONAL GROUP, LL | -39,880 | -71.4% | 15,961 |
| Pictet Asset Management Holding SA | -39,717 | -5.1% | 733,431 |
| BANK OF AMERICA CORP /DE | -37,924 | -43.9% | 48,460 |
| CITIGROUP INC | -35,088 | -83.5% | 6,949 |
| CHARLES SCHWAB INVESTMENT MANAGEMEN | -27,202 | -9.5% | 257,729 |