— Know what they know.
Not Investment Advice
Also trades as: 0JDI.L (LSE) · $vol 0M

IONS NASDAQ

Ionis Pharmaceuticals, Inc.
1W: -2.2% 1M: -2.4% 3M: -21.5% YTD: -45.5% 1Y: -39.3% 3Y: -6.7% 5Y: +43.5%
$43.96
+0.54 (+1.24%)
After Hours: $43.72 (-0.24, -0.55%)
Weekly Expected Move ±5.4%
$38 $41 $43 $45 $48
NASDAQ · Healthcare · Biotechnology · Tech Score Sell · Power 40 · $7.3B mcap · 163M float · 2.12% daily turnover · Short 39% of daily vol
Credit Risk of going bust: higher than 52% of companies Debt: 25.1% of company value Bonds: $115.2M held by 65 funds → details ▾
Of US companies ranked in the middle of the pack, about 1 in 580 filed for bankruptcy within a year (2020-2025).
If the stock fell to about $1.24 (down 97%), Ionis Pharmaceuticals, Inc. would be worth roughly what it owes.
Total debt $2.42B against a stock market value of $7.22B.
Distance to default 4.94 (Merton model): prices to 2026-10-26, balance sheet 2026-06-30, debt counted $1.20B (short-term plus half of long-term), stock volatility 44.8%; Altman Z'' 1.30. A ranking and a back-test, not a forecast.
Bond figures are fund-reported marks (SEC N-PORT) as of Jul 2026. How these are computed.

📊 Key Metrics

TTM
$874M
Revenue
-7.4% YoY
$-565M
Net Income
-110.6% YoY
$-559M
Free Cash Flow
-91.4% YoY
99.0%
Gross Margin
-38.2%
Op. Margin
-42.8%
Net Margin

💰 Income Flow

How revenue becomes profit

💵 Cash Flow

⚠️ Cash Burn Where cash goes

🏦 Balance Sheet

Assets = Liabilities + Equity

📈 Financial Health

Profitability

ROE-105.4%
ROA-18.9%
ROIC-58.5%

Valuation

P/E-12.7
P/B16.5
EV/EBITDA3.1

Leverage

Debt/Equity5.50
Current Ratio7.88
Interest Cov.-5.6x

Quality Scores

Piotroski F3/9
Altman Z2.36
Beneish M-2.49

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms