Also trades as: 0JDI.L (LSE) · $vol 0M
IONS Institutional Ownership
Ionis Pharmaceuticals, Inc.
1W: -3.2%
1M: -3.5%
3M: -18.6%
YTD: -44.8%
1Y: -38.0%
3Y: -4.8%
5Y: +40.5%
$43.96
+0.54 (+1.24%)
Weekly Expected Move ±5.4%
$38
$41
$43
$45
$48
Credit Risk of going bust: higher than 52% of companies Debt: 24.9% of company value Bonds: $115.2M held by 65 funds → details ▾
Of US companies ranked in the middle of the pack, about 1 in 580 filed for bankruptcy within a year (2020-2025).
If the stock fell to about $1.24 (down 97%), Ionis Pharmaceuticals, Inc. would be worth roughly what it owes.
Total debt $2.42B against a stock market value of $7.31B.
Distance to default 4.96 (Merton model): prices to 2026-10-27, balance sheet 2026-06-30, debt counted $1.20B (short-term plus half of long-term), stock volatility 44.8%; Altman Z'' 1.30. A ranking and a back-test, not a forecast.
Bond figures are fund-reported marks (SEC N-PORT) as of Jul 2026. How these are computed.
If the stock fell to about $1.24 (down 97%), Ionis Pharmaceuticals, Inc. would be worth roughly what it owes.
Total debt $2.42B against a stock market value of $7.31B.
Distance to default 4.96 (Merton model): prices to 2026-10-27, balance sheet 2026-06-30, debt counted $1.20B (short-term plus half of long-term), stock volatility 44.8%; Altman Z'' 1.30. A ranking and a back-test, not a forecast.
Bond figures are fund-reported marks (SEC N-PORT) as of Jul 2026. How these are computed.
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Institutional Ownership — IONS
567
Institutional Holders
+1 vs prior quarter
0.0%
Ownership
+0.00pp
$14B
Total Invested
68
New Positions
200
Increased
207
Reduced
45
Closed
0.68
Put/Call Ratio
Ownership Trends
Top Institutional Holders (616 total)
| # | Holder | Shares | Value | Change | Change % | Holding Period | Filing |
|---|---|---|---|---|---|---|---|
| 1 | FMR LLC | 24,631,956 | $1.1B | +75,319 | +0.3% | 43Q | SEC ↗ |
| 2 | Capital World Investors | 21,669,226 | $953M | +482,857 | +2.3% | 13Q | SEC ↗ |
| 3 | BlackRock, Inc. | 10,704,660 | $471M | +262,184 | +2.5% | 8Q | SEC ↗ |
| 4 | VANGUARD PORTFOLIO MANAGEMENT LLC | 7,859,529 | $346M | +50,627 | +0.6% | 2Q | SEC ↗ |
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 7,651,415 | $336M | +1,259,599 | +19.7% | 13Q | SEC ↗ |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 7,211,497 | $317M | +93,167 | +1.3% | 2Q | SEC ↗ |
| 7 | TWO SIGMA INVESTMENTS, LP | 6,252,342 | $275M | +394,713 | +6.7% | 37Q | SEC ↗ |
| 8 | ROYAL BANK OF CANADA | 6,182,479 | $272M | +2,380,664 | +62.6% | 43Q | SEC ↗ |
| 9 | STATE STREET CORP | 4,334,848 | $191M | +339,284 | +8.5% | 43Q | SEC ↗ |
| 10 | T. Rowe Price Investment Management, I | 3,959,372 | $174M | -2,199,655 | -35.7% | 17Q | SEC ↗ |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 3,584,024 | $158M | -400,308 | -10.0% | 43Q | SEC ↗ |
| 12 | PRICE T ROWE ASSOCIATES INC /MD | 3,184,500 | $140M | +159,249 | +5.3% | 16Q | SEC ↗ |
| 13 | JPMORGAN CHASE & CO | 2,671,717 | $117M | +308,150 | +13.0% | 43Q | SEC ↗ |
| 14 | Artisan Partners Limited Partnership | 2,640,024 | $116M | +581,716 | +28.3% | 10Q | SEC ↗ |
| 15 | Tweedy, Browne Co LLC | 2,280,311 | $100M | +4,686 | +0.2% | 18Q | SEC ↗ |
| 16 | Deep Track Capital, LP | 2,200,000 | $97M | +250,000 | +12.8% | 15Q | SEC ↗ |
| 17 | GOLDMAN SACHS GROUP INC | 2,109,945 | $93M | +410,098 | +24.1% | 15Q | SEC ↗ |
| 18 | BAKER BROS. ADVISORS LP | 2,047,727 | $90M | — | +0.0% | 4Q | SEC ↗ |
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,979,669 | $87M | — | +0.0% | 4Q | SEC ↗ |
| 20 | AMERICAN CENTURY COMPANIES INC | 1,947,076 | $86M | +283,273 | +17.0% | 6Q | SEC ↗ |
| 21 | FRANKLIN RESOURCES INC | 1,623,377 | $71M | +48,354 | +3.1% | 5Q | SEC ↗ |
| 22 | Sixth Street Partners Management Compa NEW | 1,605,054 | $71M | — | +0.0% | 1Q | SEC ↗ |
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT I | 1,605,054 | $71M | +21,788 | +1.4% | 15Q | SEC ↗ |
| 24 | BARCLAYS PLC | 1,603,136 | $70M | +1,313,262 | +453.0% | 43Q | SEC ↗ |
| 25 | Pictet Asset Management Holding SA | 1,596,998 | $70M | +162,003 | +11.3% | 12Q | SEC ↗ |
| 26 | UBS AM, a distinct business unit of UB | 1,454,672 | $64M | -20,960 | -1.4% | 43Q | SEC ↗ |
| 27 | Polar Capital Holdings Plc | 1,454,021 | $64M | +624,510 | +75.3% | 5Q | SEC ↗ |
| 28 | Alyeska Investment Group, L.P. | 1,417,916 | $62M | +944,766 | +199.7% | 5Q | SEC ↗ |
| 29 | NOMURA ASSET MANAGEMENT INTERNATIONAL | 1,300,392 | $57M | +515,111 | +65.6% | 3Q | SEC ↗ |
| 30 | MORGAN STANLEY | 1,281,444 | $56M | +254,935 | +24.8% | 43Q | SEC ↗ |
| 31 | Invesco Ltd. | 1,120,707 | $49M | -156,651 | -12.3% | 43Q | SEC ↗ |
| 32 | VANGUARD FIDUCIARY TRUST CO | 1,060,845 | $47M | +36,468 | +3.6% | 2Q | SEC ↗ |
| 33 | Bellevue Group AG | 972,258 | $43M | -846,407 | -46.5% | 42Q | SEC ↗ |
| 34 | GROUPAMA ASSET MANAGMENT | 937,083 | $41M | +112,543 | +13.6% | 11Q | SEC ↗ |
| 35 | NORTHERN TRUST CORP | 913,610 | $40M | +45,431 | +5.2% | 43Q | SEC ↗ |
| 36 | Capital International Investors NEW | 823,764 | $36M | — | +0.0% | 1Q | SEC ↗ |
| 37 | Davern Capital Partners, LP | 798,709 | $35M | +411,806 | +106.4% | 3Q | SEC ↗ |
| 38 | BANK OF AMERICA CORP /DE | 790,990 | $35M | -49,608 | -5.9% | 15Q | SEC ↗ |
| 39 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMEN | 787,263 | $35M | -616,770 | -43.9% | 4Q | SEC ↗ |
| 40 | GW&K Investment Management, LLC | 746,966 | $33M | -32,383 | -4.2% | 7Q | SEC ↗ |
| 41 | BNP PARIBAS ASSET MANAGEMENT Holding S | 734,219 | $32M | -173,314 | -19.1% | 11Q | SEC ↗ |
| 42 | Nuveen, LLC | 726,282 | $32M | +77,786 | +12.0% | 6Q | SEC ↗ |
| 43 | Connor, Clark & Lunn Investment Manage | 684,236 | $30M | -189,853 | -21.7% | 9Q | SEC ↗ |
| 44 | Eversept Partners, LP | 664,684 | $29M | +32,584 | +5.2% | 21Q | SEC ↗ |
| 45 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 655,454 | $29M | -17,404 | -2.6% | 8Q | SEC ↗ |
| 46 | MASSACHUSETTS FINANCIAL SERVICES CO /M | 651,816 | $29M | -14,300 | -2.1% | 5Q | SEC ↗ |
| 47 | NEUBERGER BERMAN GROUP LLC | 633,533 | $28M | +190,261 | +42.9% | 17Q | SEC ↗ |
| 48 | ARROWSTREET CAPITAL, LIMITED PARTNERSH | 632,028 | $28M | -105,831 | -14.3% | 4Q | SEC ↗ |
| 49 | UBS Group AG | 624,874 | $27M | -183,569 | -22.7% | 43Q | SEC ↗ |
| 50 | TimesSquare Capital Management, LLC | 614,070 | $27M | +338,396 | +122.8% | 2Q | SEC ↗ |
Recent Activity
New Positions (20)
| Holder | Shares | Value |
|---|---|---|
| Sixth Street Partners Management Co | 1,605,054 | $71M |
| Capital International Investors | 823,764 | $36M |
| Freestone Grove Partners LP | 339,967 | $15M |
| Life Cycle Investment Partners Ltd | 219,896 | $10M |
| Eagle Health Investments LP | 194,577 | $9M |
| NORGES BANK | 114,359 | $5M |
| Sovran Advisors, LLC | 84,984 | $4M |
| BANK OF NOVA SCOTIA | 68,548 | $3M |
| Jupiter Topco LLC | 68,191 | $3M |
| Y-Intercept (Hong Kong) Ltd | 67,374 | $3M |
| SCHRODER INVESTMENT MANAGEMENT GROU | 58,865 | $3M |
| Ethic Inc. | 31,679 | $1M |
| JUPITER ASSET MANAGEMENT LTD | 25,949 | $1M |
| BI Asset Management Fondsmaeglersel | 25,727 | $1M |
| Graham Capital Management, L.P. | 16,717 | $735K |
| BIT Capital GmbH | 16,300 | $717K |
| DARK FOREST CAPITAL MANAGEMENT LP | 15,511 | $682K |
| Mitsubishi UFJ Trust & Banking Corp | 13,446 | $591K |
| Militia Capital Management LLC | 11,400 | $501K |
| Arete Wealth Advisors, LLC | 10,885 | $479K |
Sold Out (20)
| Holder | Prev Shares | Prev Value |
|---|---|---|
| Tri Locum Partners LP | 557,174 | $24M |
| Zurich Insurance Group Ltd/FI | 239,645 | $11M |
| Ikarian Capital, LLC | 127,038 | $6M |
| Integral Health Asset Management, L | 125,000 | $5M |
| Balyasny Asset Management L.P. | 120,577 | $5M |
| Skandinaviska Enskilda Banken AB (p | 115,293 | $5M |
| HEALTHCARE OF ONTARIO PENSION PLAN | 110,000 | $5M |
| WINTON GROUP Ltd | 106,532 | $5M |
| SIMPLEX TRADING, LLC | 96,647 | $4M |
| Lisanti Capital Growth, LLC | 75,699 | $3M |
| Bridgewater Associates, LP | 67,706 | $3M |
| PDT Partners, LLC | 54,365 | $2M |
| Alpine Global Management, LLC | 53,600 | $2M |
| TUDOR INVESTMENT CORP ET AL | 48,244 | $2M |
| Mariner, LLC | 47,740 | $2M |
| Atika Capital Management LLC | 47,488 | $2M |
| ACADIAN ASSET MANAGEMENT LLC | 34,691 | $2M |
| Twin Tree Management, LP | 32,476 | $1M |
| PRELUDE CAPITAL MANAGEMENT, LLC | 29,658 | $1M |
| STEPHENS INC /AR | 26,761 | $1M |
Biggest Increases (20)
| Holder | Added | Change % | Total Shares |
|---|---|---|---|
| ROYAL BANK OF CANADA | +2,380,664 | +62.6% | 6,182,479 |
| BARCLAYS PLC | +1,313,262 | +453.0% | 1,603,136 |
| WELLINGTON MANAGEMENT GROUP LLP | +1,259,599 | +19.7% | 7,651,415 |
| Alyeska Investment Group, L.P. | +944,766 | +199.7% | 1,417,916 |
| Polar Capital Holdings Plc | +624,510 | +75.3% | 1,454,021 |
| Artisan Partners Limited Partnershi | +581,716 | +28.3% | 2,640,024 |
| NOMURA ASSET MANAGEMENT INTERNATION | +515,111 | +65.6% | 1,300,392 |
| Capital World Investors | +482,857 | +2.3% | 21,669,226 |
| Davern Capital Partners, LP | +411,806 | +106.4% | 798,709 |
| GOLDMAN SACHS GROUP INC | +410,098 | +24.1% | 2,109,945 |
| TWO SIGMA INVESTMENTS, LP | +394,713 | +6.7% | 6,252,342 |
| STATE STREET CORP | +339,284 | +8.5% | 4,334,848 |
| TimesSquare Capital Management, LLC | +338,396 | +122.8% | 614,070 |
| JANE STREET GROUP, LLC | +311,829 | +162.6% | 503,647 |
| JPMORGAN CHASE & CO | +308,150 | +13.0% | 2,671,717 |
| Qube Research & Technologies Ltd | +291,096 | +679.2% | 333,952 |
| NOMURA HOLDINGS INC | +288,112 | +252.6% | 402,192 |
| AMERICAN CENTURY COMPANIES INC | +283,273 | +17.0% | 1,947,076 |
| Carmignac Gestion | +268,000 | +505.7% | 321,000 |
| BlackRock, Inc. | +262,184 | +2.5% | 10,704,660 |
Biggest Decreases (20)
| Holder | Reduced | Change % | Total Shares |
|---|---|---|---|
| T. Rowe Price Investment Management | -2,199,655 | -35.7% | 3,959,372 |
| Bellevue Group AG | -846,407 | -46.5% | 972,258 |
| MILLENNIUM MANAGEMENT LLC | -762,634 | -72.5% | 288,872 |
| CITADEL ADVISORS LLC | -706,250 | -74.9% | 236,284 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGE | -616,770 | -43.9% | 787,263 |
| AMERIPRISE FINANCIAL INC | -592,439 | -89.7% | 67,705 |
| Squarepoint Ops LLC | -585,897 | -84.3% | 109,379 |
| GEODE CAPITAL MANAGEMENT, LLC | -400,308 | -10.0% | 3,584,024 |
| J. Goldman & Co LP | -194,894 | -82.8% | 40,366 |
| ExodusPoint Capital Management, LP | -191,439 | -84.3% | 35,645 |
| Connor, Clark & Lunn Investment Man | -189,853 | -21.7% | 684,236 |
| TD Asset Management Inc | -189,406 | -35.7% | 340,548 |
| UBS Group AG | -183,569 | -22.7% | 624,874 |
| DIMENSIONAL FUND ADVISORS LP | -182,467 | -68.3% | 84,748 |
| Trexquant Investment LP | -182,107 | -85.2% | 31,538 |
| BNP PARIBAS ASSET MANAGEMENT Holdin | -173,314 | -19.1% | 734,219 |
| Invesco Ltd. | -156,651 | -12.3% | 1,120,707 |
| Hudson Bay Capital Management LP | -150,100 | -50.9% | 145,000 |
| D. E. Shaw & Co., Inc. | -132,558 | -30.9% | 297,041 |
| Engineers Gate Manager LP | -118,987 | -88.9% | 14,840 |