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Also trades as: 0JDI.L (LSE) · $vol 0M

IONS Smart Money

Ionis Pharmaceuticals, Inc.
1W: -3.2% 1M: -3.5% 3M: -18.6% YTD: -44.8% 1Y: -38.0% 3Y: -4.8% 5Y: +40.5%
$43.96
+0.54 (+1.24%)
Pre-Market: $43.65 (-0.31, -0.71%)
Weekly Expected Move ±5.4%
$38 $41 $43 $45 $48
NASDAQ · Healthcare · Biotechnology · Tech Score Sell · Power 40 · $7.3B mcap · 163M float · 2.12% daily turnover · Short 39% of daily vol
Credit Risk of going bust: higher than 52% of companies Debt: 24.9% of company value Bonds: $115.2M held by 65 funds → details ▾
Of US companies ranked in the middle of the pack, about 1 in 580 filed for bankruptcy within a year (2020-2025).
If the stock fell to about $1.24 (down 97%), Ionis Pharmaceuticals, Inc. would be worth roughly what it owes.
Total debt $2.42B against a stock market value of $7.31B.
Distance to default 4.96 (Merton model): prices to 2026-10-27, balance sheet 2026-06-30, debt counted $1.20B (short-term plus half of long-term), stock volatility 44.8%; Altman Z'' 1.30. A ranking and a back-test, not a forecast.
Bond figures are fund-reported marks (SEC N-PORT) as of Jul 2026. How these are computed.

🏦 Institutional Activity

Latest: Q2 2026
567
Institutions Holding
+1 vs prior
188.9%
Ownership
+21.15%
68 New
200 Increased
207 Reduced
45 Closed

👔 Insider Trades

25 records
Date Name Title Type Shares Price Value Filing
2026-10-16 Swayze Eric officer: evp research S-Sale 53 $43.54 $2K Filing
2026-10-16 Devers Shannon L. officer: evp, chief human resources ofc S-Sale 1,357 $43.54 $59K Filing
2026-08-31 Birchler Brian officer: evp, corp and development ops J-J 58 $51.31 $3K Filing
2026-08-31 Monia Brett P officer: chief executive officer J-J 98 $51.31 $5K Filing
2026-08-31 O'NEIL PATRICK R. officer: evp clo & general counsel J-J 63 $51.31 $3K Filing
2026-08-31 BENNETT C FRANK officer: evp, chief scientific officer J-J 110 $51.31 $6K Filing
2026-07-31 Hayden Michael R director P-Purchase 5,000 $51.60 $258K Filing
2026-07-30 Hayden Michael R director P-Purchase 15,000 $53.38 $801K Filing
2026-07-07 BENNETT C FRANK officer: evp, chief scientific officer S-Sale 15,000 $85.46 $1.3M Filing
2026-07-07 BENNETT C FRANK officer: evp, chief scientific officer S-Sale 5,536 $83.58 $463K Filing
2026-07-07 Kordasiewicz Holly B. officer: evp, chief development officer S-Sale 362 $84.30 $31K Filing
2026-07-07 Diaz Allene M. director S-Sale 10,111 $85.42 $864K Filing
2026-07-01 KLEIN JOSEPH III director S-Sale 11,419 $79.04 $903K Filing
2026-07-01 KLEIN JOSEPH III director S-Sale 99 $79.45 $8K Filing
2026-06-26 Schneider Eugene officer: evp, chf clinical develop ofcr S-Sale 26,000 $81.05 $2.1M Filing
2026-06-26 O'NEIL PATRICK R. officer: evp clo & general counsel S-Sale 3,069 $80.00 $246K Filing
2026-06-26 Baroldi Joseph officer: evp, chief business officer S-Sale 5,635 $80.16 $452K Filing
2026-06-26 Monia Brett P officer: chief executive officer S-Sale 50,000 $80.59 $4.0M Filing
2026-06-25 Swayze Eric officer: evp research S-Sale 10,602 $79.18 $839K Filing
2026-06-25 Monia Brett P officer: chief executive officer S-Sale 21,072 $78.49 $1.7M Filing
2026-06-24 Monia Brett P officer: chief executive officer S-Sale 14,565 $78.41 $1.1M Filing
2026-06-15 BERTHELSEN SPENCER R director S-Sale 8,000 $73.49 $588K Filing
2026-06-12 Kordasiewicz Holly B. officer: evp, chief development officer S-Sale 19,842 $74.05 $1.5M Filing
2026-06-12 Kordasiewicz Holly B. officer: evp, chief development officer S-Sale 41,004 $73.09 $3.0M Filing
2026-06-01 BERTHELSEN SPENCER R director S-Sale 8,000 $75.67 $605K Filing

🏛️ Congressional Trades

7 records
Date Politician Chamber Type Amount Filing
2023-03-14 Ro Khanna House Sell $1,001 - $15,000 Filing
2023-03-06 Daniel Goldman House Sell $1,001 - $15,000 Filing
2022-12-06 Ro Khanna House Buy $1,001 - $15,000 Filing
2019-06-24 Donna Shalala House Sell $1,001 - $15,000 Filing
2019-05-08 Donna Shalala House Buy $1,001 - $15,000 Filing
2016-01-20 Sheldon Whitehouse Senate Sell $1,001 - $15,000 Filing
2016-01-20 Sheldon Whitehouse Senate Sell $1,001 - $15,000 Filing

🏦 Top Institutional Holders

20 holders
Holder Shares Value Date Reported Filing
FMR LLC 24,631,956 $2.0B +75,319 2026-06-30 Filing
Capital World Investors 21,669,226 $1.7B +482,857 2026-06-30 Filing
BlackRock, Inc. 10,704,660 $849M +262,184 2026-06-30 Filing
VANGUARD PORTFOLIO MANAGEMENT LLC 7,859,529 $623M +50,627 2026-06-30 Filing
WELLINGTON MANAGEMENT GROUP LLP 7,651,415 $607M +1,259,599 2026-06-30 Filing
VANGUARD CAPITAL MANAGEMENT LLC 7,211,497 $572M +93,167 2026-06-30 Filing
TWO SIGMA INVESTMENTS, LP 6,252,342 $496M +394,713 2026-06-30 Filing
ROYAL BANK OF CANADA 6,182,479 $490M +2,380,664 2026-06-30 Filing
STATE STREET CORP 4,334,848 $344M +339,284 2026-06-30 Filing
GEODE CAPITAL MANAGEMENT, LLC 3,584,024 $295M -400,308 2026-06-30 Filing
JPMORGAN CHASE & CO 2,671,717 $216M +308,150 2026-06-30 Filing
Artisan Partners Limited Partnership 2,640,024 $209M +581,716 2026-06-30 Filing
Tweedy, Browne Co LLC 2,280,311 $181M +4,686 2026-06-30 Filing
Deep Track Capital, LP 2,200,000 $174M +250,000 2026-06-30 Filing
GOLDMAN SACHS GROUP INC 2,109,945 $167M +410,098 2026-06-30 Filing
BAKER BROS. ADVISORS LP 2,047,727 $162M — 2026-06-30 Filing
DEERFIELD MANAGEMENT COMPANY, L.P. 1,979,669 $157M — 2026-06-30 Filing
AMERICAN CENTURY COMPANIES INC 1,947,076 $154M +283,273 2026-06-30 Filing
FRANKLIN RESOURCES INC 1,623,377 $129M +48,354 2026-06-30 Filing
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,605,054 $127M +21,788 2026-06-30 Filing

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms